One‐Pot Multicomponent Reaction: A Highly Versatile Strategy for the Construction of Valuable Nitrogen‐Containing Heterocycles

S Nandi, R Jamatia, R Sarkar, FK Sarkar… - …, 2022 - Wiley Online Library
A large portion of the chemical subspace is the multi‐component reaction (MCR). Apart from
Domino reactions, MCR is one of the most promising routes for one‐pot synthesis. Thus …

[HTML][HTML] Synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported by nano-catalysts

MM Hammouda, MM Rashed, KM Elattar… - RSC advances, 2023 - pubs.rsc.org
Nano-catalysts are of special character for the synthesis of organic molecules with high
efficiency, and exceptional physicochemical properties. The objective of this study was to …

One‐pot and two‐pot methods for chalcone derived pyrimidines synthesis and applications

S Farooq, Z Ngaini - Journal of Heterocyclic Chemistry, 2021 - Wiley Online Library
Chalcone‐derived pyrimidine is a well‐known heterocyclic compound that is commonly
present in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) bio‐isosteres …

Recent Developments in the MCRs Synthesis of Pyridopyrimidines and Spiro‐Pyridopyrimidines

M Mamaghani, R Hossein Nia - Journal of Heterocyclic …, 2017 - Wiley Online Library
Because of biological and medicinal properties of pyridopyrimidines, synthesis of these
heterocycles has attracted the interest of organic and medicinal chemists. This review …

Recent progress in the chemistry of bicyclic 6–6 systems: chemistry of pyrido[1,2-a]pyrimidines

KM Elattar, R Rabie, MM Hammouda - Monatshefte für Chemie-Chemical …, 2017 - Springer
The present review provides a study on the structural features, reactions, and synthetic
methodologies of pyrido [1, 2-a] pyrimidines. Thus, the synthetic procedures and organic …

Mild, General, and Regioselective Synthesis of 2-Aminopyridines from Pyridine N-Oxides via N-(2-Pyridyl) pyridinium Salts

H Xiong, AT Hoye - Synlett, 2022 - thieme-connect.com
A synthesis of 2-aminopyridines from pyridine N-oxides via their corresponding N-(2-pyridyl)
pyridinium salts has been demonstrated and investigated. The reaction sequence features a …

Transition metal-free one-pot synthesis of nitrogen-containing heterocycles

S Kumari, D Kishore, S Paliwal, R Chauhan… - Molecular …, 2016 - Springer
One-pot heterocyclic synthesis is an exciting research area as it can open routes for the
development of otherwise complex transformations in organic synthesis. Heterocyclic …

Naturally inspired pyrimidines analogues for alzheimer's disease

S Singh, M Dhanawat, S Gupta… - Current …, 2021 - ingentaconnect.com
Alzheimer's disease (AD) is a multifarious and developing neurodegenerative disorder. The
treatment of AD is still a challenge and availability of drug therapy on the basis of symptoms …

Discovery of novel tricyclic thiazepine derivatives as anti-drug-resistant cancer agents by combining diversity-oriented synthesis and converging screening approach

J Xiang, Z Zhang, Y Mu, X Xu, S Guo, Y Liu… - ACS combinatorial …, 2016 - ACS Publications
An efficient discovery strategy by combining diversity-oriented synthesis and converging
cellular screening is described. By a three-round screening process, we identified novel …

[HTML][HTML] The Flögel-three-component reaction with dicarboxylic acids–an approach to bis (β-alkoxy-β-ketoenamides) for the synthesis of complex pyridine and …

MK Bera, M Domínguez, P Hommes… - Beilstein Journal of …, 2014 - beilstein-journals.org
An extension of the substrate scope of the Flögel-three-component reaction of lithiated
alkoxyallenes, nitriles and carboxylic acids is presented. The use of dicarboxylic acids …