Protein kinase C epsilon (PKCɛ), a novel calcium-independent PKC isoform, has been
shown to be a transforming oncogene. PKCɛ-mediated oncogenic activity is linked to its …

Loss-of-function mutations in the Arabidopsis (Arabidopsis thaliana) ENHANCED DISEASE
RESISTANCE1 (EDR1) gene confer enhanced resistance to powdery mildew infection …

Host cell factors can either positively or negatively regulate the assembly and egress of HIV-
1 particles from infected cells. Recent reports have identified a previously uncharacterized …

Ubiquitination is an essential post-translational modification that regulates signalling and
protein turnover in eukaryotic cells. Specificity of ubiquitination is driven by ubiquitin E3 …

To identify novel oncogenic E3 ubiquitin ligases as anticancer targets, we screened an E3
ubiquitin ligase siRNA library containing siRNA pools against 555 individual E3s using the …

Ubiquitination controls and fine‐tunes many signaling processes driving immunity,
inflammation, and cancer. The E3 ubiquitin ligase HOIL‐1 (heme‐oxidized IRP 2 ubiquitin …

Accumulating evidence suggests that ubiquitination plays a role in cancer by changing the
function of key cellular proteins. Previously, we isolated BCA2 gene from a library enriched …

Stimulation of cells with epidermal growth factor (EGF) induces internalization and partial
degradation of the EGF receptor (EGFR) by the endo-lysosomal pathway. For continuous …

Phosphotyrosine‐binding domains, typified by the SH2 (S rc h omology 2) and PTB
domains, are critical upstream components of signal transduction pathways. The E3 …

Activation of the epidermal growth factor receptor (EGFR) results in internalization and
ubiquitin-dependent endosomal sorting, leading to lysosomal degradation. Here we …