Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II–
peptide complexes to control phagosomal infections, help B cells, regulate tissue …

Within the past decade, the field of immunotherapy has revolutionized the treatment of many
cancers with the development and regulatory approval of various immune-checkpoint …

Cancer immunotherapy has revolutionised cancer treatment, with immune checkpoint
blockade (ICB) therapy and adoptive cell therapy (ACT) increasingly becoming standard of …

Background Regular physical activity is the prime modality for the prevention of numerous
non-communicable diseases and has also been advocated for resilience against COVID-19 …

Conventional type 1 dendritic cells (cDC1) are thought to perform antigen cross-
presentation, which is required to prime CD8+ T cells,, whereas cDC2 are specialized for …

The first-generation COVID-19 vaccines have been effective in mitigating severe illness and
hospitalization, but recurring waves of infections are associated with the emergence of …

As crucial antigen presenting cells, dendritic cells (DCs) play a vital role in tumor
immunotherapy. Taking into account the many recent advances in DC biology, we discuss …

Current success of immunotherapy in cancer has drawn attention to the subsets of TH cells
in the tumor which are critical for activation of anti-tumor response either directly by …

Cancer immunotherapy aims to promote the activity of cytotoxic T lymphocytes (CTLs) within
a tumour, assist the priming of tumour-specific CTLs in lymphoid organs and establish …

Background Programmed cell death 1 (PD-1) blockade induces tumor regression in patients
with advanced esophageal squamous cell carcinoma (ESCC); however, little is known about …