Piperacillin–tazobactam is a β-lactam/β-lactamase inhibitor combination with a broad
spectrum of antibacterial activity that includes Gram-positive and-negative aerobic and …

Synopsis Combining tazobactam, a β-lactamase inhibitor, with the ureidopenicillin,
piperacillin, successfully restores the activity of piperacillin against β-lactamase-producing …

The pharmacokinetics of piperacillin and tazobactam were assessed after single-dose
administration to 47 infants and children. Study subjects ranging in age from 2 months to 12 …

This study examined the effect of various levels of renal impairment on the probability of
achieving free drug concentrations that exceed the MIC for 50% of the dosing interval (50% f …

TO THE EDITOR—In January 2023, the Clinical and Laboratory Standards Institute (CLSI)
revised the piperacillintazobactam (PTZ) interpretive criteria against Pseudomonas …

Piperacillin/tazobactam is the most recently approved combination of a β-lactam agent with
an inhibitor of bacterial β-lactamases. It has a broader spectrum than do preceding inhibitor …

The genus Klebsiella consists of non-motile, aerobic and facultatively anaerobic, Gram
negative rods. At the time of writing, the genus Klebsiella comprises K. pneumoniae subsp …

A simple and fast high‐performance liquid chromatography with tandem mass spectrometry
method for quantification of tazobactam, piperacillin, and meropenem in human plasma has …

Piperacillin combined with tazobactam at a fixed concentration (4 μg/ml) and a ratio (8: 1)
was tested against 5029 aerobic isolates and 447 fastidious organisms, including …

Pharmacokinetic and pharmacodynamic considerations in in vitro susceptibility testing are
described, and the integration of pharmacokinetic and pharmacodynamic concepts in …