Nitric oxide signalling in kidney regulation and cardiometabolic health

M Carlström - Nature reviews nephrology, 2021 - nature.com
The prevalence of cardiovascular and metabolic disease coupled with kidney dysfunction is
increasing worldwide. This triad of disorders is associated with considerable morbidity and …

The noncanonical pathway for in vivo nitric oxide generation: the nitrate-nitrite-nitric oxide pathway

V Kapil, RS Khambata, DA Jones, K Rathod… - Pharmacological …, 2020 - ASPET
In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …

Side effects of acetazolamide: a systematic review and meta-analysis assessing overall risk and dose dependence

CN Schmickl, RL Owens, JE Orr… - BMJ open …, 2020 - bmjopenrespres.bmj.com
Introduction Acetazolamide (AZM) is used for various conditions (eg, altitude sickness, sleep
apnoea, glaucoma), but therapy is often limited by its side effect profile. Our objective was to …

Central blood pressure for the management of hypertension: Is it a practical clinical tool in current practice?

HM Cheng, SY Chuang, TD Wang… - The Journal of …, 2020 - Wiley Online Library
Since noninvasive central blood pressure (BP) measuring devices are readily available,
central BP has gained growing attention regarding its clinical application in the management …

Post-exercise hypotension and skeletal muscle oxygenation is regulated by nitrate-reducing activity of oral bacteria

C Cutler, M Kiernan, JR Willis, L Gallardo-Alfaro… - Free Radical Biology …, 2019 - Elsevier
Post-exercise hypotension (PEH) is a common physiological phenomenon leading to lower
blood pressure after acute exercise, but it is not fully understood how this intriguing …

[HTML][HTML] Oral nitrite treatment increases S-nitrosylation of vascular protein kinase C and attenuates the responses to angiotensin II

LC Pinheiro, GH Oliveira-Paula, GC Ferreira… - Redox Biology, 2021 - Elsevier
Nitrate and nitrite supplement deficient endogenous nitric oxide (NO) formation. While these
anions may generate NO, recent studies have shown that circulating nitrite levels do not …

Orally administered sodium nitrite prevents the increased α-1 adrenergic vasoconstriction induced by hypertension and promotes the S-nitrosylation of calcium …

GH Oliveira-Paula, RIM Batista, S Stransky… - Biochemical …, 2023 - Elsevier
The unsatisfactory rates of adequate blood pressure control among patients receiving
antihypertensive treatment calls for new therapeutic strategies to treat hypertension. Several …

[HTML][HTML] Protective Effect of Red Okra (Abelmoschus esculentus (L.) Moench) Pods against Sodium Nitrite-Induced Liver Injury in Mice

SPA Wahyuningsih, AA Mwendolwa… - Veterinary Medicine …, 2021 - hindawi.com
Vegetables, drinking water, and preserved meats may contain sodium nitrite (NaNO 2),
which causes liver disease by inducing oxidative stress. Phytochemicals are highly …

[HTML][HTML] The effect of orally administered nitrate on renal function and blood pressure in a randomized, placebo-controlled, crossover study in healthy subjects

AM Østergaard, MH Vrist, JB Rosenbæk, JA Ejlersen… - Nitric Oxide, 2023 - Elsevier
Background Several studies have shown inorganic nitrate/nitrite to reduce blood pressure in
both healthy subjects and hypertensive patients. An effect presumably caused through …

Modulation of oral microbiota: A new frontier in exercise supplementation

R Bescos, ZLS Brookes, LA Belfield… - PharmaNutrition, 2020 - Elsevier
Research on the human microbiome has flourished over the last decade due to the essential
role that bacterial communities have in host physiology and health. Recent studies have …