The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …

Background Migraine is a disabling and chronic neurovascular headache disorder.
Trigeminal vascular activation and release of calcitonin gene-related peptide (CGRP) play a …

Targeting CGRP has proved to be efficacious, tolerable, and safe to treat migraine; however,
many patients with migraine do not benefit from drugs that antagonize the CGRPergic …

Calcitonin gene-related peptide (CGRP) has 37 amino acids. Initially, CGRP had
vasodilatory and nociceptive effects. As research progressed, evidence revealed that the …

Abstract Background and Purpose Calcitonin gene‐related peptide (CGRP) is involved in
migraine pathophysiology. CGRP can signal through two receptors. The canonical CGRP …

Background Real-world data on the effectiveness of calcitonin gene-related peptide
monoclonal antibodies (CGRP mAbs) in migraine patients are needed. Methods We …

The somatosensory nervous system surveils external stimuli at barrier tissues, regulating
innate immune cells under infection and inflammation. The roles of sensory neurons in …

Objective To investigate whether levcromakalim (a KATP channel opener) induces migraine-
like headache in people with persistent post-traumatic headache who had no known history …

Emerging evidence suggests that nerves within the tumor microenvironment play a crucial
role in regulating angiogenesis. Neurotransmitters and neuropeptides released by nerves …

Background Chronic primary pain (CPP) is an intractable pain of unknown cause with
significant emotional distress and/or dysfunction that is a leading factor of disability globally …