Bayesian weighing of electron cryo-microscopy data for integrative structural modeling
Cryo-electron microscopy (cryo-EM) has become a mainstream technique for determining
the structures of complex biological systems. However, accurate integrative structural …
the structures of complex biological systems. However, accurate integrative structural …
Bacteriophage protein–protein interactions
Abstract Bacteriophages T7, λ, P22, and P2/P4 (from Escherichia coli), as well as ϕ29 (from
Bacillus subtilis), are among the best-studied bacterial viruses. This chapter summarizes …
Bacillus subtilis), are among the best-studied bacterial viruses. This chapter summarizes …
Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones
M Wilkinson, LA Troman, WAK Wan Nur Ismah… - Elife, 2016 - elifesciences.org
Our previous paper (Wilkinson et al, 2016) used high-resolution cryo-electron microscopy to
solve the structure of the Escherichia coli RecBCD complex, which acts in both the repair of …
solve the structure of the Escherichia coli RecBCD complex, which acts in both the repair of …
Impact of target site distribution for Type I restriction enzymes on the evolution of methicillin-resistant Staphylococcus aureus (MRSA) populations
GA Roberts, PJ Houston, JH White, K Chen… - Nucleic acids …, 2013 - academic.oup.com
A limited number of Methicillin-resistant Staphylococcus aureus (MRSA) clones are
responsible for MRSA infections worldwide, and those of different lineages carry unique …
responsible for MRSA infections worldwide, and those of different lineages carry unique …
DNA mimic proteins: functions, structures, and bioinformatic analysis
DNA mimic proteins have DNA-like negative surface charge distributions, and they function
by occupying the DNA binding sites of DNA binding proteins to prevent these sites from …
by occupying the DNA binding sites of DNA binding proteins to prevent these sites from …
Genome-wide association study of gastric cancer- and duodenal ulcer-derived Helicobacter pylori strains reveals discriminatory genetic variations and novel …
VP Tuan, K Yahara, HDQ Dung, TT Binh… - Microbial …, 2021 - microbiologyresearch.org
Genome-wide association studies (GWASs) can reveal genetic variations associated with a
phenotype in the absence of any hypothesis of candidate genes. The problem of false …
phenotype in the absence of any hypothesis of candidate genes. The problem of false …
The structure of the KlcA and ArdB proteins reveals a novel fold and antirestriction activity against Type I DNA restriction systems in vivo but not in vitro
D Serfiotis-Mitsa, AP Herbert, GA Roberts… - Nucleic acids …, 2010 - academic.oup.com
Plasmids, conjugative transposons and phage frequently encode anti-restriction proteins to
enhance their chances of entering a new bacterial host that is highly likely to contain a Type …
enhance their chances of entering a new bacterial host that is highly likely to contain a Type …
Identification of a Pseudomonas aeruginosa PAO1 DNA Methyltransferase, Its Targets, and Physiological Roles
S Doberenz, D Eckweiler, O Reichert, V Jensen… - MBio, 2017 - Am Soc Microbiol
ABSTRACT DNA methylation is widespread among prokaryotes, and most DNA methylation
reactions are catalyzed by adenine DNA methyltransferases, which are part of restriction …
reactions are catalyzed by adenine DNA methyltransferases, which are part of restriction …
Everything OLD is new again: How structural, functional, and bioinformatic advances have redefined a neglected nuclease family
EW Dot, LC Thomason, JS Chappie - Molecular Microbiology, 2023 - Wiley Online Library
Overcoming lysogenization defect (OLD) proteins are a conserved family of ATP‐powered
nucleases that function in anti‐phage defense. Recent bioinformatic, genetic, and …
nucleases that function in anti‐phage defense. Recent bioinformatic, genetic, and …
Genetic basis of I-complex plasmid stability and conjugation
Plasmids are major drivers of increasing antibiotic resistance, necessitating an urgent need
to understand their biology. Here we describe a detailed dissection of the molecular …
to understand their biology. Here we describe a detailed dissection of the molecular …