Type I DNA restriction/modification (RM) enzymes are molecular machines found in the
majority of bacterial species. Their early discovery paved the way for the development of …

Staphylococcus aureus displays a clonal population structure in which horizontal gene
transfer between different lineages is extremely rare. This is due, in part, to the presence of a …

CRISPR-Cas systems store fragments of invader DNA as spacers to recognize and clear
those same invaders in the future. Spacers can also be acquired from the host's genomic …

DNA methylation events mediated by orphan methyltransferases modulate various cellular
processes like replication, repair and transcription. Bacteria and archaea also harbor DNA …

The epigenetics of bacteria, and bacteria with a reduced genome in particular, is of great
interest, but is still poorly understood. Mycoplasma gallisepticum, a representative of the …

DNA mimic proteins have evolved to control DNA-binding proteins by competing with the
target DNA for binding to the protein. The Ocr protein of bacteriophage T7 is the most …

DNA double-strand breaks (DSBs) are one of the most lethal forms of DNA damage that is
not efficiently repaired in prokaryotes. Certain microorganisms can handle chromosomal …

The T4 phage protein Arn (Anti restriction nuclease) was identified as an inhibitor of the
restriction enzyme McrBC. However, until now its molecular mechanism remained unclear …

We identify a new subgroup of Type I Restriction-Modification enzymes that modify cytosine
in one DNA strand and adenine in the opposite strand for host protection. Recognition …

Anti-restriction and anti-modification (anti-RM) is the ability to prevent cleavage by DNA
restriction–modification (RM) systems of foreign DNA entering a new bacterial host. The …