The G72 gene is one of the most susceptible genes to schizophrenia and is contained
exclusively in the genomes of primates. The product of the G72 gene modulates the activity …

The article by Liu et al.(1) on the structure of type I DNA restriction and modification enzymes
purports to significantly advance our understanding of these enzymes and proposes a …

Enterococci are Gram-positive enteric bacteria that have co-evolved with animals since
terrestrialization. While generally considered commensals, over the last several decades …

Bacteria have evolved numerous mechanisms to resist the constant assault of viruses
(called bacteriophages, or simply phages) that can infect and kill them. Restriction …

Cryo-electron microscopy has become a mainstream structural biology technique. It often
allows us to determine near-atomic resolution structures of biological architectures that have …

Streptococcus pyogenes is responsible for a wide variety of human diseases ranging from
minor skin infections and pharyngitis to more serious complications such as rheumatic fever …

Bacteriophages are the most abundant organisms on the planet and are a major driving
force in bacterial evolution. As obligate intracellular parasites, phages are reliant on their …

ABSTRACT DNA methylation is widespread among prokaryotes, and most DNA methylation
reactions are catalyzed by adenine DNA methyltransferases, which are part of restriction …

Modification (HsdM) and specificity (HsdS) subunits are constituents of an active
methyltransferase (MTase) of multifunctional type I restriction enzymes. To provide a …

Type I restriction–modification (R–M) systems are comprised of two multi-subunit enzymes
with complementary functions: the methyltransferase (∼ 160kDa), responsible for …