Idiopathic calcium oxalate (CaOx) stones often develop attached to Randall's plaque
present on kidney papillary surfaces. Similar to the plaques formed during vascular …

Purpose: Idiopathic calcium oxalate kidney stones form while attached to Randall plaques,
the subepithelial deposits on renal papillary surfaces. Plaque formation and growth …

Kidney stone disease causes significant morbidity and increases health care utilization. In
this work, we decipher the cellular and molecular niche of the human renal papilla in …

Calcium oxalate (CaOx) kidney stones are formed attached to Randall's plaques (RPs) or
Randall's plugs. Mechanisms involved in the formation and growth are poorly understood. It …

Crystals can trigger a wide range of kidney injuries that can lead to acute kidney injury,
chronic kidney disease, renal colic or nephrocalcinosis, depending on the localization and …

Objective: The National Health and Nutrition Examination Survey (NHANES) has
demonstrated an upward trend in prevalence of kidney stones (KSs) in the past 30 years …

In humans, approximately 60 mg of ascorbic acid (AA) breaks down in the body each day
and has to be replaced by a dietary intake of 70 mg in women and 90 mg in men to maintain …

Metabolic syndrome is manifested by visceral obesity, hypertension, glucose intolerance,
hyperinsulinism, and dyslipidemia. According to the CDC, metabolic syndrome in the US …

The E3 ubiquitin ligase NEDD4-2 (encoded by the Nedd4L gene) regulates the amiloride-
sensitive epithelial Na+ channel (ENaC/SCNN1) to mediate Na+ homeostasis. Mutations in …

Kidney stones develop attached to sub-epithelial plaques of calcium phosphate (CaP)
crystals (termed Randall's plaque) and/or form as a result of occlusion of the openings of the …