Medical diagnostics and treatment has advanced from a one size fits all science to treatment
of the patient as a unique individual. Currently, this is limited solely to genetic analysis …

Systems vaccinology has proven a fascinating development in the last decade. Where
traditionally vaccine development has been dominated by trial and error, systems …

Genetic studies associate killer cell immunoglobulin-like receptors (KIRs) and their HLA
class I ligands with a variety of human diseases. The basis for these associations and the …

Type I and III interferons (IFNs) are robustly induced during infections and protect cells
against viral infection. Both type I and III IFNs are also produced at low levels in the thymus …

T cells help orchestrate immune responses to pathogens, and their aberrant regulation can
trigger autoimmunity. Recent studies highlight that a threshold number of T cells (a quorum) …

Oncolytic viruses (OVs), known for their cancer-killing characteristics, also overturn tumor-
associated defects in antigen presentation through the MHC class I pathway and induce …

While antigen processing and presentation (APP) by the major histocompatibility complex
class I (MHC‐I) molecules have been extensively studied, a question arises as to whether …

Vaccination with vaccinia virus (VACV) elicits heterotypic immunity to smallpox, monkeypox,
and mousepox, the mechanistic basis for which is poorly understood. It is generally …

Lung transplantation can be lifesaving in end-stage cystic fibrosis (CF), but long-term
survival is limited by chronic lung allograft dysfunction (CLAD). Persistent upper airway …

The role of regulatory T cells (Tregs) in limiting responses to pathogens in tissues remains
poorly described. We used scRNA-Seq and a newly generated Foxp3-lineage reporter line …