[HTML][HTML] Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential
Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress.
However, its source, pathophysiological role and possible therapeutic potential if targeted …
However, its source, pathophysiological role and possible therapeutic potential if targeted …
[HTML][HTML] Role and mechanisms of mitophagy in liver diseases
The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular
redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both …
redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both …
[HTML][HTML] Electrochemical transformations catalyzed by cytochrome P450s and peroxidases
Cytochrome P450s (Cyt P450s) and peroxidases are enzymes featuring iron heme cofactors
that have wide applicability as biocatalysts in chemical syntheses. Cyt P450s are a family of …
that have wide applicability as biocatalysts in chemical syntheses. Cyt P450s are a family of …
PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses
LL Mazaleuskaya, K Sangkuhl, CF Thorn… - Pharmacogenetics …, 2015 - journals.lww.com
Pharmacokinetics Acetaminophen has a high oral bioavailability (88%); it is well absorbed
and reaches the peak blood concentration within 90min after ingestion [5]. APAP is not …
and reaches the peak blood concentration within 90min after ingestion [5]. APAP is not …
Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing
Current drug-safety assays for hepatotoxicity rely on biomarkers with low predictive power.
The production of radical species, specifically reactive oxygen species (ROS) and reactive …
The production of radical species, specifically reactive oxygen species (ROS) and reactive …
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose
Acetaminophen (APAP) overdose can cause hepatotoxicity and even liver failure. N-
acetylcysteine (NAC) is still the only FDA-approved antidote against APAP overdose 40 …
acetylcysteine (NAC) is still the only FDA-approved antidote against APAP overdose 40 …
[HTML][HTML] A critical perspective on 3D liver models for drug metabolism and toxicology studies
AS Serras, JS Rodrigues, M Cipriano… - Frontiers in cell and …, 2021 - frontiersin.org
The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …
Ellagic acid: Pharmacological activities and molecular mechanisms involved in liver protection
WR García-Niño, C Zazueta - Pharmacological Research, 2015 - Elsevier
Traditional drugs or therapies rarely have effects on regression of chronic liver diseases,
which result in many cases from sustained oxidative stress. In recent years, ellagic acid (EA) …
which result in many cases from sustained oxidative stress. In recent years, ellagic acid (EA) …
[HTML][HTML] Acetaminophen toxicity: novel insights into mechanisms and future perspectives
A Ramachandran, H Jaeschke - Gene expression, 2018 - ncbi.nlm.nih.gov
Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the US,
and decades of intense study of its pathogenesis resulted in the development of the antidote …
and decades of intense study of its pathogenesis resulted in the development of the antidote …
[HTML][HTML] Liver injury induced by paracetamol and challenges associated with intentional and unintentional use
L Rotundo, N Pyrsopoulos - World journal of hepatology, 2020 - ncbi.nlm.nih.gov
Drug induced liver injury (DILI) is a common cause of acute liver injury. Paracetamol, also
known as acetaminophen, is a widely used anti-pyretic that has long been established to …
known as acetaminophen, is a widely used anti-pyretic that has long been established to …