Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress.
However, its source, pathophysiological role and possible therapeutic potential if targeted …

The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular
redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both …

Cytochrome P450s (Cyt P450s) and peroxidases are enzymes featuring iron heme cofactors
that have wide applicability as biocatalysts in chemical syntheses. Cyt P450s are a family of …

Pharmacokinetics Acetaminophen has a high oral bioavailability (88%); it is well absorbed
and reaches the peak blood concentration within 90min after ingestion [5]. APAP is not …

Current drug-safety assays for hepatotoxicity rely on biomarkers with low predictive power.
The production of radical species, specifically reactive oxygen species (ROS) and reactive …

Acetaminophen (APAP) overdose can cause hepatotoxicity and even liver failure. N-
acetylcysteine (NAC) is still the only FDA-approved antidote against APAP overdose 40 …

The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …

Traditional drugs or therapies rarely have effects on regression of chronic liver diseases,
which result in many cases from sustained oxidative stress. In recent years, ellagic acid (EA) …

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the US,
and decades of intense study of its pathogenesis resulted in the development of the antidote …

Drug induced liver injury (DILI) is a common cause of acute liver injury. Paracetamol, also
known as acetaminophen, is a widely used anti-pyretic that has long been established to …