Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the
United States and mechanisms of liver injury induced by APAP overdose have been the …

Drug-induced liver injury (DILI) is one among the common adverse drug reactions and the
leading causes of drug development attritions, black box warnings, and post-marketing …

Acetaminophen (APAP) is a widely used analgesic drug, which can cause severe liver injury
after an overdose. The intracellular signaling mechanisms of APAP-induced cell death such …

Acetaminophen or paracetamol (APAP) overdose is a common cause of liver injury.
Silymarin (SLM) is a hepatoprotective agent widely used for treating liver injury of different …

Acetaminophen (APAP)-induced liver injury is an important clinical and toxicological
problem. Understanding the mechanisms and modes of cell death are vital for the …

Acetaminophen (APAP), which is also known as paracetamol or N-acetyl-p-aminophenol is
a safe and potent drug for fever, pain and inflammation when used at its normal therapeutic …

This is an overview of the metabolic activation of drugs, natural products, physiological
compounds, and general chemicals by the catalytic activity of cytochrome P450 enzymes …

Although necrosis is recognized as the main mode of cell death induced by acetaminophen
(APAP) overdose in animals and humans, more recently an increasing number of …

Background In the present study, the poncirin which is flavonoid-7-o-glycosides (isolated
from the Poncirus trifoliata) in nature was evaluated against the Carbon tetra chloride …

Acetaminophen (APAP) overdose is the most frequent cause of acute liver failure in the USA
and many other countries. Although the metabolism and pathogenesis of APAP has been …