[HTML][HTML] Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice
Mitochondria damage plays a critical role in acetaminophen (APAP)-induced necrosis and
liver injury. Cells can adapt and protect themselves by removing damaged mitochondria via …
liver injury. Cells can adapt and protect themselves by removing damaged mitochondria via …
The development and hepatotoxicity of acetaminophen: reviewing over a century of progress
MR McGill, JA Hinson - Drug metabolism reviews, 2020 - Taylor & Francis
Acetaminophen (APAP) was first synthesized in the 1800s, and came on the market
approximately 65 years ago. Since then, it has become one of the most used drugs in the …
approximately 65 years ago. Since then, it has become one of the most used drugs in the …
Paracetamol: overdose-induced oxidative stress toxicity, metabolism, and protective effects of various compounds in vivo and in vitro
X Wang, Q Wu, A Liu, A Anadón… - Drug metabolism …, 2017 - Taylor & Francis
Paracetamol (APAP) is one of the most widely used and popular over-the-counter analgesic
and antipyretic drugs in the world when used at therapeutic doses. APAP overdose can …
and antipyretic drugs in the world when used at therapeutic doses. APAP overdose can …
Are some people at increased risk of paracetamol-induced liver injury? A critical review of the literature
TM Caparrotta, DJ Antoine, JW Dear - European journal of clinical …, 2018 - Springer
Purpose Paracetamol is one of the world's most commonly used drugs. In overdose, it is well
established to be hepatotoxic. The aim of this review was to identify factors that have been …
established to be hepatotoxic. The aim of this review was to identify factors that have been …
Phenolic sulfates as new and highly abundant metabolites in human plasma after ingestion of a mixed berry fruit purée
RC Pimpao, MR Ventura, RB Ferreira… - British Journal of …, 2015 - cambridge.org
Bioavailability studies are vital to assess the potential impact of bioactive compounds on
human health. Although conjugated phenolic metabolites derived from colonic metabolism …
human health. Although conjugated phenolic metabolites derived from colonic metabolism …
Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans
CD Williams, ML Bajt, MR Sharpe, MR McGill… - Toxicology and applied …, 2014 - Elsevier
Following acetaminophen (APAP) overdose there is an inflammatory response triggered by
the release of cellular contents from necrotic hepatocytes into the systemic circulation which …
the release of cellular contents from necrotic hepatocytes into the systemic circulation which …
Pathogenesis of COVID‐19 described through the lens of an undersulfated and degraded epithelial and endothelial glycocalyx
HN du Preez, C Aldous, MR Hayden… - The FASEB …, 2022 - Wiley Online Library
The glycocalyx surrounds every eukaryotic cell and is a complex mesh of proteins and
carbohydrates. It consists of proteoglycans with glycosaminoglycan side chains, which are …
carbohydrates. It consists of proteoglycans with glycosaminoglycan side chains, which are …
Mechanisms of inflammatory liver injury and drug-induced hepatotoxicity
BL Woolbright, H Jaeschke - Current pharmacology reports, 2018 - Springer
Abstract Purpose of Review This article provides a brief overview of mechanisms of
inflammatory liver injury and how this applies to drug hepatotoxicity with a particular …
inflammatory liver injury and how this applies to drug hepatotoxicity with a particular …
Mitochondrial–lysosomal axis in acetaminophen hepatotoxicity
Acetaminophen (APAP) toxicity is the most common cause of acute liver failure and a major
indication for liver transplantion in the United States and Europe. Although significant …
indication for liver transplantion in the United States and Europe. Although significant …
4-methylpyrazole protects against acetaminophen-induced acute kidney injury
Acetaminophen (APAP) hepatotoxicity is the most common cause of acute liver failure in the
United States, and while a significant percentage of APAP overdose patients develop kidney …
United States, and while a significant percentage of APAP overdose patients develop kidney …