ABSTRACT Introduction: Busulfan (Bu) is an alkylating agent with a limited therapeutic
margin and exhibits inter-patient variability in pharmacokinetics (PK). Despite decades of …

Acetaminophen (APAP) overdose is a major cause of acute liver failure (ALF). Numerous
studies have shown that APAP hepatotoxicity in mice involves mitochondrial dysfunction …

Background: Drug overdose or chemical exposures are the main causes of acute liver injury
(ALI). Severe liver injury can develop into liver failure that is an important cause of liver …

Liver injury due to acetaminophen (APAP) overdose is the major cause of acute liver failure
in the United States. While treatment with N-acetylcysteine is the current standard of care for …

Background: Liver injury induced by drugs has become a primary reason for acute liver
disease and therefore posed a potential regulatory and clinical challenge over the past few …

Previous studies have shown that tumor necrosis factor (TNF)-α is a mediator of
hepatotoxicity in liver injury. Moreover, TNF-α has also been reported to have a protective …

Glutathione (GSH) plays many important roles in maintaining intracellular redox
homeostasis, and determining its real-time levels in the biological system is essential for the …

In this review we focus on the pathophysiology of CRC-related pain and discuss currently
applied pain management. Pain is a symptom reported by over 70% of colorectal cancer …

Acetaminophen (APAP) is a widely used analgesic. However, APAP overdose is hepatotoxic
and is the primary cause of acute liver failure in the developed world. The mechanism of …

Acetaminophen (APAP) overdose causes severe hepatotoxicity in animals and humans.
However, the mechanisms underlying the gender differences in susceptibility to APAP …