Acetaminophen (APAP) overdose-induced fatal hepatotoxicity is majorly characterized by
overwhelmingly increased oxidative stress while enhanced nuclear factor-erythroid 2 …

Liver, the major metabolic organ in the body, is known for its remarkable capacity to
regenerate. Whereas partial hepatectomy (PHx) is a popular model for the study of liver …

Liver injury and acute liver failure caused by acetaminophen (APAP) overdose is the
clinically most important drug toxicity in Western countries. Mechanistic investigations have …

We previously demonstrated that pharmacological induction of autophagy protected against
acetaminophen (APAP)-induced liver injury in mice by clearing damaged mitochondria …

The analgesic and antipyretic compound acetaminophen (paracetamol) is one of the most
used drugs worldwide. Acetaminophen overdose is also the most common cause for acute …

The intestinal mucosa and liver have long been considered as the main sites of drug
metabolism, and the contribution of gut microbiota to drug metabolism has been under …

The nonsteroidal anti-inflammatory drugs (NSAIDs) are amongst the most commonly
detected classes of pharmaceuticals in freshwater environments, with paracetamol being the …

Acetaminophen (APAP) hepatotoxicity remains the leading cause of drug-induced liver
injury due to the lack of safe and effective therapeutic agents. Berberine (BBR) is a natural …

Previous studies have shown that silymarin protects against various types of drug-induced
liver injury, but whether the protective mechanism of silymarin against acetaminophen …

Background An overdose of acetaminophen (APAP), the main cause of acute liver failure
(ALF), induces oxidative stress that ultimately causes mitochondrial impairment and …