IL-1β production is critically regulated by cytosolic molecular complexes, termed
inflammasomes. Different inflammasome complexes have been described to date. While all …

Recent literature has pointed to the existence of inflammasome-mediated inflammatory
pathways in central nervous system (CNS) disorders and associated changes in behavior …

Inflammation has been linked to multiple degenerative and acute diseases as well as the
aging process. Moreover, mitochondrial alterations play a central role in these processes …

Depression has been widely accepted as a major psychiatric disease affecting nearly 350
million people worldwide. Research focus is now shifting from studying the extrinsic and …

Stroke is one of the major devastating diseases with no effective medical therapeutics.
Because of the high rate of disability and mortality among stroke patients, new treatments …

Objective—Psoriasis is an inflammatory skin disease which heightens the risk of
cardiovascular disease. This study directly investigated vascular endothelial health and …

Cardiovascular diseases are known as the leading cause of morbidity and mortality
worldwide. As an innate immune signaling complex, inflammasomes can be activated by …

An acute myocardial infarction (AMI) induces a sterile inflammatory response that facilitates
further heart injury and promotes adverse cardiac remodeling. Interleukin-1β (IL-1β) plays a …

Activation of NOD-like receptor (NLR) family and pyrin domain containing 3 (NLRP3)
inflammasome contributes to inflammation and may lead to atherosclerosis. The NLRP3 …

Aberrant production of adipokines, a group of adipocytes-derived hormones, is considered
one of the most important pathological characteristics of obesity. In individuals with obesity …