[HTML][HTML] Pharmaceutical treatment of bone loss: From animal models and drug development to future treatment strategies
MB Brent - Pharmacology & Therapeutics, 2023 - Elsevier
Animal models are fundamental to advance our knowledge of the underlying
pathophysiology of bone loss and to study pharmaceutical countermeasures against it. The …
pathophysiology of bone loss and to study pharmaceutical countermeasures against it. The …
[HTML][HTML] Current knowledge and novel frontiers in lower urinary tract dysfunction after spinal cord injury: Basic research perspectives
N Wada, S Karnup, K Kadekawa, N Shimizu… - Urological …, 2022 - journals.lww.com
This review article aims to summarize the recent advancement in basic research on lower
urinary tract dysfunction (LUTD) following spinal cord injury (SCI) above the sacral level. We …
urinary tract dysfunction (LUTD) following spinal cord injury (SCI) above the sacral level. We …
Directing induced pluripotent stem cell derived neural stem cell fate with a three-dimensional biomimetic hydrogel for spinal cord injury repair
L Fan, C Liu, X Chen, Y Zou, Z Zhou, C Lin… - … applied materials & …, 2018 - ACS Publications
Current treatment approaches for spinal cord injuries (SCIs) are mainly based on cellular
transplantation. Induced pluripotent stem cells (iPSCs) without supply constraints and ethical …
transplantation. Induced pluripotent stem cells (iPSCs) without supply constraints and ethical …
A systematic review of animal models of disuse-induced bone loss
Objective Several different animal models are used to study disuse-induced bone loss. This
systematic review aims to give a comprehensive overview of the animal models of disuse …
systematic review aims to give a comprehensive overview of the animal models of disuse …
The effect of neutralization of nerve growth factor (NGF) on bladder and urethral dysfunction in mice with spinal cord injury
N Wada, T Shimizu, N Shimizu… - Neurourology and …, 2018 - Wiley Online Library
Aims To investigate the role of nerve growth factor (NGF) in lower urinary tract dysfunction in
mice with spinal cord injury (SCI). Methods Using 4‐week SCI mice, single‐filling cystometry …
mice with spinal cord injury (SCI). Methods Using 4‐week SCI mice, single‐filling cystometry …
[HTML][HTML] Early detrusor application of botulinum toxin a results in reduced bladder hypertrophy and fibrosis after spinal cord injury in a rodent model
JY Bushnell, LN Cates, JE Hyde, CP Hofstetter… - Toxins, 2022 - mdpi.com
Following spinal cord injury (SCI), pathological reflexes develop that result in altered
bladder function and sphincter dis-coordination, with accompanying changes in the …
bladder function and sphincter dis-coordination, with accompanying changes in the …
Time-dependent progression of neurogenic lower urinary tract dysfunction after spinal cord injury in the mouse model
T Saito, D Gotoh, N Wada, P Tyagi… - American Journal …, 2021 - journals.physiology.org
This study evaluated the time-course changes in bladder and external urinary sphincter
(EUS) activity and the expression of mechanosensitive channels in lumbosacral dorsal root …
(EUS) activity and the expression of mechanosensitive channels in lumbosacral dorsal root …
Therapeutic effects of p38 mitogen-activated protein kinase inhibition on hyperexcitability of capsaicin sensitive bladder afferent neurons in mice with spinal cord injury
T Suzuki, T Shimizu, S Karnup, N Shimizu, J Ni… - Life Sciences, 2023 - Elsevier
Aims Nerve growth factor (NGF) has been implicated as a key molecule of pathology-
induced changes in C-fiber afferent nerve excitability, which contributes to the emergence of …
induced changes in C-fiber afferent nerve excitability, which contributes to the emergence of …
[HTML][HTML] Mid-lumbar (L3) epidural stimulation effects on bladder and external urethral sphincter in non-injured and chronically transected urethane-anesthetized rats
D Medina-Aguiñaga, RF Hoey, NL Wilkins… - Scientific Reports, 2023 - nature.com
Recent pre-clinical and clinical spinal cord epidural stimulation (scES) experiments
specifically targeting the thoracolumbar and lumbosacral circuitries mediating lower urinary …
specifically targeting the thoracolumbar and lumbosacral circuitries mediating lower urinary …
[HTML][HTML] Molecular Mechanism Operating in Animal Models of Neurogenic Detrusor Overactivity: A Systematic Review Focusing on Bladder Dysfunction of Neurogenic …
A Ferreira, D Nascimento, CD Cruz - International Journal of Molecular …, 2023 - mdpi.com
Neurogenic detrusor overactivity (NDO) is a severe lower urinary tract disorder,
characterized by urinary urgency, retention, and incontinence, as a result of a neurologic …
characterized by urinary urgency, retention, and incontinence, as a result of a neurologic …