Simple Summary Cutaneous squamous cell carcinomas (SCCs) are the most common
tumors in patients suffering from the genetic disorder epidermolysis bullosa (EB). These …

Recent large-scale GWAS and large epidemiologic studies have accelerated the discovery
of genes and environmental factors that contribute to the risk of keratinocyte carcinoma (KC) …

Background Cutaneous squamous cell carcinoma (SCC) is the leading cause of death in
patients with recessive dystrophic epidermolysis bullosa (RDEB). However, the survival time …

Background Epidermolysis bullosa (EB) is a group of rare genetic skin disorders that
primarily manifest as blisters and erosions following mild mechanical trauma. Despite the …

To date, more than 200 monogenic, often devastating, skin diseases have been described.
Because of unmet medical needs, development of long-lasting and curative therapies has …

Keratin intermediate filaments play an important role in maintaining the integrity of the skin
structure. Understanding the importance of this subject is possible with the investigation of …

Rare skin diseases include more than 800 diseases affecting more than 6.8 million patients
worldwide. However, only 100 drugs have been developed for treating rare skin diseases in …

In this study we used a genetic extracellular matrix (ECM) disease to identify mechanisms
associated with aggressive behavior of cutaneous squamous cell carcinoma (cSCC). cSCC …

Dystrophic epidermolysis bullosa is a rare genetic skin disorder caused by COL7A1
sequence variations that result in type VII collagen deficits and cutaneous and …

Simple Summary Cutaneous squamous cell carcinoma (cSCC) is a recognized but
infrequent complication of hidradenitis suppurativa (HS). After performing a thorough …