Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …

Potassium channels participate in many biological functions, from ion homeostasis to
generation and modulation of the electrical membrane potential. They are involved in a …

Neuroinflammation is a pathophysiological hallmark of multiple sclerosis and has a close
mechanistic link to neurodegeneration. Although this link is potentially targetable, robust …

Background Our previous study in patients with cerebellar ataxias of different causes
showed significant benefit of riluzole after 8 weeks. We aimed to confirm these results in …

The pulmonary epithelium serves as a barrier to prevent access of the inspired luminal
contents to the subepithelium. In addition, the epithelium dictates the initial responses of the …

Influenza A virus (IAV) uses the low pH in late endocytic vacuoles as a cue for penetration by
membrane fusion. Here, we analyzed the prefusion reactions that prepare the core for …

Rationale: Ischemic stroke is a leading cause of morbidity and mortality worldwide.
Recanalization of the occluded vessel is essential but not sufficient to guarantee brain …

Diabetic retinopathy is a heterogeneous retinal degenerative disease with the microvascular
dysfunction being recognized as a hallmark of the advanced stage. In this study, we …

Aberrant immune responses represent the underlying cause of central nervous system
(CNS) autoimmunity, including multiple sclerosis (MS). Recent evidence implicated the …

Over the last decade, we have seen an enormous increase in the number of experimental
studies on two-pore-domain potassium channels (K 2P-channels). The collection of reviews …