Objective The purpose of this clinical trial was to examine the effect of omega-3 fatty acids
(W-3 FAs), nanocurcumin and their combination on serum levels and gene expression of …

The blood–brain barrier (BBB) is a physiological barrier maintaining a specialized brain
micromilieu that is necessary for proper neuronal function. Endothelial tight junctions and …

Interferon gamma (IFNγ) is a pro-inflammatory cytokine, first described as a secreted
molecule capable of interfering with viral replication. Since then, numerous other important …

Multiple sclerosis (MS) is characterized by autoimmune damage to the central nervous
system. All the current drugs for MS target the immune system. Although effective in reducing …

Allergic rhinitis (AR) is a common disease affecting 400 million of the population worldwide.
Nasal epithelial cells form a barrier against the invasion of environmental pathogens. These …

Depression is a disease that is particularly frequent, affecting up to 20% of the population in
W estern countries. The origins of this pathology involve multiple genes as well as …

Mechanotransduction by the trabecular meshwork (TM) is an essential component of
intraocular pressure regulation in the vertebrate eye. This process is compromised in …

This study used response surface methodology to determine the optimal conditions for
extraction of polysaccharides from Pyracantha. fortuneana (PSPF), and studied the …

A dysregulated cellular Ca2+ homeostasis is involved in multiple pathologies including
cancer. Changes in Ca2+ signaling caused by altered fluxes through ion channels and …

Living organisms perceive and respond to a diverse range of mechanical stimuli. A variety of
mechanosensitive ion channels have evolved to facilitate these responses, but the …