Plasma kallikrein modulates immune cell trafficking during neuroinflammation via PAR2 and bradykinin release
K Göbel, CM Asaridou, M Merker… - Proceedings of the …, 2019 - National Acad Sciences
Blood–brain barrier (BBB) disruption and transendothelial trafficking of immune cells into the
central nervous system (CNS) are pathophysiological hallmarks of neuroinflammatory …
central nervous system (CNS) are pathophysiological hallmarks of neuroinflammatory …
Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease
N Mykicki, AM Herrmann, N Schwab… - Science translational …, 2016 - science.org
In inflammation-associated progressive neuroinflammatory disorders, such as multiple
sclerosis (MS), inflammatory infiltrates containing T helper 1 (TH1) and TH17 cells cause …
sclerosis (MS), inflammatory infiltrates containing T helper 1 (TH1) and TH17 cells cause …
[HTML][HTML] Bunyavirus requirement for endosomal K+ reveals new roles of cellular ion channels during infection
In order to multiply and cause disease a virus must transport its genome from outside the cell
into the cytosol, most commonly achieved through the endocytic network. Endosomes …
into the cytosol, most commonly achieved through the endocytic network. Endosomes …
[HTML][HTML] Altered expression of ion channels in white matter lesions of progressive multiple sclerosis: what do we know about their function?
Despite significant advances in our understanding of the pathophysiology of multiple
sclerosis (MS), knowledge about contribution of individual ion channels to axonal …
sclerosis (MS), knowledge about contribution of individual ion channels to axonal …
[HTML][HTML] Deficiency of TREK-1 potassium channel exacerbates blood-brain barrier damage and neuroinflammation after intracerebral hemorrhage in mice
Y Fang, Y Tian, Q Huang, Y Wan, L Xu, W Wang… - Journal of …, 2019 - Springer
Background Intracerebral hemorrhage (ICH) is a devastating medical emergency with high
mortality and severe neurological deficit. ICH-related poor outcomes are due to a …
mortality and severe neurological deficit. ICH-related poor outcomes are due to a …
Temperature sensitivity of two-pore (K2P) potassium channels
ER Schneider, EO Anderson, EO Gracheva… - Current topics in …, 2014 - Elsevier
At normal body temperature, the two-pore potassium channels TREK-1 (K 2P 2.1/KCNK2),
TREK-2 (K 2P 10.1/KCNK10), and TRAAK (K 2P 4.1/KCNK2) regulate cellular excitability by …
TREK-2 (K 2P 10.1/KCNK10), and TRAAK (K 2P 4.1/KCNK2) regulate cellular excitability by …
[HTML][HTML] Traumatic brain injury causes selective, CD74-dependent peripheral lymphocyte activation that exacerbates neurodegeneration
Introduction Traumatic brain injury (TBI), a significant cause of death and disability, causes,
as in any injury, an acute, innate immune response. A key component in the transition …
as in any injury, an acute, innate immune response. A key component in the transition …
[HTML][HTML] Topological remodeling of cortical perineuronal nets in focal cerebral ischemia and mild hypoperfusion
Despite the crucial role of perineuronal nets (PNNs) in neural plasticity and neurological
disorders, their ultrastructural organization remains largely unresolved. We have developed …
disorders, their ultrastructural organization remains largely unresolved. We have developed …
Chemokine CCL17 is expressed by dendritic cells in the CNS during experimental autoimmune encephalomyelitis and promotes pathogenesis of disease
C Ruland, H Renken, I Kuzmanov, AF Mehr… - Brain, behavior, and …, 2017 - Elsevier
The CC chemokine ligand 17 (CCL17) and its cognate CC chemokine receptor 4 (CCR4)
are known to control leukocyte migration, maintenance of TH 17 cells, and regulatory T cell …
are known to control leukocyte migration, maintenance of TH 17 cells, and regulatory T cell …
“Disease modifying nutricals” for multiple sclerosis
K Schmitz, J Barthelmes, L Stolz, S Beyer… - Pharmacology & …, 2015 - Elsevier
The association between vitamin D and multiple sclerosis has (re)-opened new interest in
nutrition and natural compounds in the prevention and treatment of this neuroinflammatory …
nutrition and natural compounds in the prevention and treatment of this neuroinflammatory …