TWIK-related K+ 1 (TREK1) potassium channels are members of the two-pore domain
potassium channel family and contribute to background potassium conductances in many …

In the recent past, a plethora of drugs have been approved for the treatment of multiple
sclerosis (MS). These therapeutics are mainly confined to immunomodulatory or …

Despite intense research, few treatments are available for most neurological disorders.
Demyelinating diseases are no exception. This is perhaps not surprising considering the …

Neuroinflammatory disorders, such as multiple sclerosis or experimental autoimmune
encephalomyelitis (EAE), an established mouse model mimicking part of the human …

Two-pore domain potassium (K2P) channels generate leak currents that are responsible for
the maintenance of the resting membrane potential, and they are thus potential drug targets …

The blood-brain barrier (BBB) forms a highly selective interface between blood and brain.
Extensive research efforts have completely changed our view of the BBB in the last years …

The blood–brain barrier (BBB) and tight junction (TJ) proteins maintain the homeostasis of
the central nervous system (CNS). The dysfunction of BBB allows peripheral T cells …

K2P potassium channels stabilize the resting membrane potential in nearly all cells and
have been implicated in several neuronal, cardiovascular, and immune diseases. DCPIB, a …

The first description of epileptic seizures due to brain tumours occurred in 19th century.
Nevertheless, after over one hundred years, scientific literature is still lacking on how …

Injury to the brain after intracerebral hemorrhage (ICH) results from numerous complex
cellular mechanisms. At present, effective therapy for ICH is limited and a better …