Abstract K 2P 2.1 (TREK1), a two-pore domain potassium channel, has emerged as
regulator of leukocyte transmigration into the central nervous system. In the context of …

This study examined the effect of neuron-endothelial coupling on the survival of neurons
after ischemia and the possible mechanism underlying that effect. Whole-cell patch-clamp …

Two-pore domain potassium (K2P) channels influence basic cellular parameters such as
resting membrane potential, cellular excitability, or intracellular Ca2+-concentration [Ca2+] i …

It remains largely unclear how thymocytes translate relative differences in T cell receptor
(TCR) signal strength into distinct developmental programs that drive the cell fate decisions …

Spinal cord injury (SCI) involves complex pathological process which can be complicated by
secondary injury. TREK‐1 is a member of the two‐pore domain potassium (K2P) channel …

Lipid signaling has been suggested to be a major pathophysiological mechanism of multiple
sclerosis (MS). With the increasing knowledge about lipid signaling, acquired data become …

Members of the two-pore domain K+ channel (K 2P) family are increasingly recognized as
being potential targets for therapeutic drugs and could play a role in the diagnosis and …

Earlier studies have shown the neuroprotective role of TWIK-related K+ channel 1 (TREK-1)
in global cerebral and spinal cord ischemia, while its function in focal cerebral ischemia has …

Key points Neuronal activity causes astrocytic volume change via K+ uptake through TREK‐
1 containing two‐pore domain potassium channels. The volume transient is terminated by …

Background Most subarachnoid hemorrhage (SAH) patients have no obvious hematoma
lesions but exhibit blood–brain barrier dysfunction and vasogenic brain edema. However …