[HTML][HTML] Genetic manipulation of brain endothelial cells in vivo
Brain endothelial cells take center stage of the blood–brain barrier. They maintain
homeostasis in the central nervous system (CNS) and are involved in the pathophysiology of …
homeostasis in the central nervous system (CNS) and are involved in the pathophysiology of …
[HTML][HTML] How leukocytes trigger opening and sealing of gaps in the endothelial barrier
D Goswami, D Vestweber - F1000Research, 2016 - ncbi.nlm.nih.gov
The entry of leukocytes into tissues requires well-coordinated interactions between the
immune cells and endothelial cells which form the inner lining of blood vessels. The …
immune cells and endothelial cells which form the inner lining of blood vessels. The …
General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation
Relapsing-remitting multiple sclerosis (MS) 2 is characterized by phases of acute
neuroinflammation followed by spontaneous remission. Termination of inflammation is …
neuroinflammation followed by spontaneous remission. Termination of inflammation is …
The transcription factor Foxd3 induces spinal cord ischemia-reperfusion injury by potentiating microRNA-214-dependent inhibition of Kcnk2
R Li, K Zhao, Q Ruan, C Meng, F Yin - Experimental & Molecular …, 2020 - nature.com
Spinal cord injury after surgical repair of the thoracic or thoracoabdominal aorta is a
devastating complication that is associated with pathological changes, including …
devastating complication that is associated with pathological changes, including …
[HTML][HTML] Zonula occludens-1 expression is reduced in nasal epithelial cells of allergic rhinitis patients
Allergic rhinitis (AR) is a common allergic disease characterized by disruption of nasal
epithelial barrier. In this study, we investigated the mRNA expression of zonula occludens-1 …
epithelial barrier. In this study, we investigated the mRNA expression of zonula occludens-1 …
Activation of the TREK-1 potassium channel improved cognitive deficits in a mouse model of Alzheimer's disease by modulating glutamate metabolism
F Li, S Zhou, X Zeng, Z Li, R Yang, X Wang… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
cognitive dysfunction. The glutamate (Glu) metabolic pathway may be a major contributor to …
cognitive dysfunction. The glutamate (Glu) metabolic pathway may be a major contributor to …
Linolenic acid provides multi-cellular protective effects after photothrombotic cerebral ischemia in rats
Y Liu, Q Sun, X Chen, L Jing, W Wang, Z Yu… - Neurochemical …, 2014 - Springer
Alpha-linolenic acid (LIN) has been shown to provide neuroprotective effects against
cerebral ischemia. LIN is a potent activator of TREK-1 channel and LIN-induced …
cerebral ischemia. LIN is a potent activator of TREK-1 channel and LIN-induced …
A novel TWIK2 channel inhibitor binds at the bottom of the selectivity filter and protects against LPS-induced experimental endotoxemia in vivo
Y Zhi, X Wu, Y Chen, X Chen, X Chen, H Luo… - Biochemical …, 2023 - Elsevier
TWIK2 channel plays a critical role in NLRP3 inflammasome activation and mice deficient in
TWIK2 channel are protected from sepsis and inflammatory lung injury. However, inhibitors …
TWIK2 channel are protected from sepsis and inflammatory lung injury. However, inhibitors …
Kv7 channel activation reduces brain endothelial cell permeability and prevents kainic acid-induced blood-brain barrier damage
C Celentano, L Carotenuto, F Miceli… - … of Physiology-Cell …, 2024 - journals.physiology.org
Ion channels in the blood-brain barrier (BBB) play a main role in controlling the interstitial
fluid composition and cerebral blood flow, and their dysfunction contributes to the disruption …
fluid composition and cerebral blood flow, and their dysfunction contributes to the disruption …
[HTML][HTML] KCa3. 1 channel inhibition leads to an ICAM-1 dependent increase of cell-cell adhesion between A549 lung cancer and HMEC-1 endothelial cells
E Bulk, N Kramko, I Liashkovich, F Glaser, H Schillers… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Early metastasis leads to poor prognosis of lung cancer patients, whose 5-year survival rate
is only 15%. We could recently show that the Ca 2+ sensitive K+ channel K Ca 3.1 promotes …
is only 15%. We could recently show that the Ca 2+ sensitive K+ channel K Ca 3.1 promotes …