Little is known about mechanisms that control vascular aging, particularly at the cell-specific
level. PPARγ (peroxisome proliferator–activated receptor-γ) exerts protective effects in the …

Aging plays a significant role in the progression of vascular diseases and vascular
dysfunction. Activation of the ADP-ribosylation factor 6 and small GTPases by inflammatory …

The Rho kinases, or ROCKs, are a family of serine-threonine kinases that serve as key
downstream effectors for Rho GTPases. The ROCKs are increasingly recognized as critical …

TiO2 nanotubes (TNTs) are attractive nanostructures for localized drug delivery. Owing to
their excellent biocompatibility and physicochemical properties, numerous functionalizations …

Abstract Whether a small GTPase RhoA plays a role in the pathology of abdominal aortic
aneurysm (AAA) has not been determined. We show here that RhoA expression is reduced …

Statins have been proposed for L-DOPA-induced dyskinesia (LID) treatment. Statin anti-
dyskinetic effects were related to the inhibition of the Ras-ERK pathway. However, the …

Depression is a common mental disease that can lead to suicide when severe. Exposure to
prenatal stress (PS) can lead to depression-like behavior in offspring, but the mechanism is …

Traditional anti-arrhythmic drugs are classified by the Vaughan-Williams classification
scheme based on their mechanisms of action, which includes effects on receptors and/or ion …

The lack of novel antimicrobial drugs in development for tuberculosis treatment has provided
an impetus for the discovery of adjunctive host-directed therapies (HDTs). Several promising …

Statins exert pleiotropic and beneficial anti-inflammatory and antioxidant effects. We have
previously reported that macrophages treated with statins increased the expression of heme …