Mucosal vaccines: Strategies and challenges

M Li, Y Wang, Y Sun, H Cui, SJ Zhu, HJ Qiu - Immunology letters, 2020 - Elsevier
Mucosal immunization has potential benefits over conventional parenteral immunization,
eliciting immune defense in both mucosal and systemic tissue for protecting from pathogen …

Intranasal vaccine: Factors to consider in research and development

H Xu, L Cai, S Hufnagel, Z Cui - International journal of pharmaceutics, 2021 - Elsevier
Most existing vaccines for human use are administered by needle-based injection.
Administering vaccines needle-free intranasally has numerous advantages over by needle …

Advances in intranasal vaccine delivery: A promising non-invasive route of immunization

E Kehagia, P Papakyriakopoulou, G Valsami - Vaccine, 2023 - Elsevier
The importance of vaccination has been proven particularly significant the last three years,
as it is revealed to be the most efficient weapon for the prevention of several infections …

Bridging nanoplatform and vaccine delivery, a landscape of strategy to enhance nasal immunity

Z Teng, LY Meng, JK Yang, Z He, XG Chen… - Journal of Controlled …, 2022 - Elsevier
Vaccination is an urgently needed and effective option to address epidemic, cancers,
allergies, and other diseases. Nasal administration of vaccines offers many benefits over …

COVID-19 vaccines (revisited) and oral-mucosal vector system as a potential vaccine platform

MU Ashraf, Y Kim, S Kumar, D Seo, M Ashraf, YS Bae - Vaccines, 2021 - mdpi.com
There are several emerging strategies for the vaccination of COVID-19 (SARS-CoV-2)
however, only a few have yet shown promising effects. Thus, choosing the right pathway and …

Different methods and formulations of drugs and vaccines for nasal administration

J Tai, M Han, D Lee, IH Park, SH Lee, TH Kim - Pharmaceutics, 2022 - mdpi.com
Nasal drug delivery is advantageous when compared with other routes of drug delivery as it
avoids the hepatic first-pass effect, blood–brain barrier penetration, and compliance issues …

Spray dried powders for nasal delivery: Process and formulation considerations

P Henriques, A Fortuna, S Doktorovová - European Journal of …, 2022 - Elsevier
Powders for nasal delivery have been recognized as advantageous dosage forms over
liquids due to increased stability and residence time on nasal mucosa, with improved …

Strategies to facilitate or block nose-to-brain drug delivery

PP Martins, HDC Smyth, Z Cui - International journal of pharmaceutics, 2019 - Elsevier
Nose-to-brain delivery has gained significant interest over the past several decades. This
has resulted in numerous strategies described to improve the delivery of drugs to the brain …

Lipid-based particles: versatile delivery systems for mucosal vaccination against infection

B Corthésy, G Bioley - Frontiers in immunology, 2018 - frontiersin.org
Vaccination is the process of administering immunogenic formulations in order to induce or
harness antigen (Ag)-specific antibody and T cell responses in order to protect against …

How to characterize a nasal product. The state of the art of in vitro and ex vivo specific methods

L Salade, N Wauthoz, J Goole, K Amighi - International journal of …, 2019 - Elsevier
Nasal delivery offers many benefits over other conventional routes of delivery (eg oral or
intravenous administration). Benefits include, among others, a fast onset of action, non …