Risk assessment of SARS-CoV-2 replicating and evolving in animals

J Zhao, M Kang, H Wu, B Sun, G Baele, WT He… - Trends in …, 2023 - cell.com
The retransmissions of SARS-CoV-2 from several mammals–primarily mink and white-tailed
deer–to humans have raised concerns for the emergence of a new animal-derived SARS …

[HTML][HTML] Cytokine response and damages in the lungs of aging Syrian hamsters on a high-fat diet infected with the SARS-CoV-2 virus

G Fomin, K Tabynov, R Islamov, N Turebekov… - Frontiers in …, 2023 - frontiersin.org
Hypertriglyceridemia, obesity, and aging are among the key risk factors for severe COVID-19
with acute respiratory distress syndrome (ARDS). One of the main prognostic biomarkers of …

SARS-CoV-2 exploits cellular RAD51 to promote viral propagation: implication of RAD51 inhibitor as a potential drug candidate against COVID-19

TX Pham, TTX Huynh, J Choi, JB Lee, SC Park… - Journal of …, 2023 - Am Soc Microbiol
ABSTRACT RAD51 is an important factor involved in the homologous recombination and
repair of DNA breaks, which has also been implicated in various virus replication processes …

A heterologous challenge rescues the attenuated immunogenicity of SARS-CoV-2 omicron BA. 1 variant in Syrian hamster model

J Ma, X Liu, M Zhou, P Chen, R Chen, J Wang… - Journal of …, 2023 - Am Soc Microbiol
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant is
becoming a dominant circulator and has several mutations in the spike glycoprotein, which …

The Effective Inhibitory Concentration of Interferon-β Correlates with Infectivity and Replication Fitness of SARS-CoV-2 Variants

J Singh, A Anantharaj, P Kumar, R Pandey… - Journal of Interferon & …, 2024 - liebertpub.com
India saw a spike in COVID-19 cases in early 2023, and this wave of infection was attributed
to XBB sublineages of SARS-CoV-2 Omicron variant. The impact of XBB wave was …

[HTML][HTML] Augmentation of Omicron BA. 1 pathogenicity in hamsters using intratracheal inoculation

JR Port, CK Yinda, C Ruckel, JE Schulz, BJ Smith… - npj Viruses, 2024 - nature.com
The Omicron BA. 1 variant of SARS-CoV-2 displays an attenuated phenotype in the Syrian
hamster after intranasal inoculation. This is characterized by reduced viral replication and …