Fasting hyperglycemia in patients with type 2 diabetes mellitus (T2DM) is attributed to
increased hepatic gluconeogenesis, which has been ascribed to increased transcriptional …

The liver plays a central role in metabolism, protein synthesis and detoxification. It
possesses unique regenerative capacity upon injury. While many factors regulating cellular …

We have identified a novel, conserved phosphatase sequence motif, KXXXXXXRP‐(X12‐
54)‐PSGH‐(X31‐54))‐SRXXXXX HXXXD, that is shared among several lipid phosphatases …

The terminal step in hepatic gluconeogenesis is catalyzed by glucose-6-phosphatase, an
enzyme activity residing in the endoplasmic reticulum and consisting of a catalytic subunit …

Definitive hematopoietic stem cells (HSCs) first appear in the aorta/gonad/mesonephros
(AGM) region and migrate to the fetal liver where they massively produce hematopoietic …

Following hepatic injury or stress, gluconeogenic and acute-phase response genes are
rapidly upregulated to restore metabolic homeostasis and limit tissue damage. Regulation of …

One of the primary basic plasma parameters within transient nonequilibrium plasmas is the
reduced electric field strength, roughly understood as the ratio of the electrical energy given …

Overproduction of glucose by the liver is the major cause of fasting hyperglycemia in both
insulin-dependent and non-insulin-dependent diabetes mellitus. The distal enzymatic step …

The operation of glucose 6‐phosphatase (EC 3.1. 3.9)(Glc6Pase) stems from the interaction
of at least two highly hydrophobic proteins embedded in the ER membrane, a heavily …

The fetal liver, the major site of hematopoiesis during embryonic development, acquires
additional functions near birth. Among the important liver functions is the response to …