Bilirubin nanomedicines for the treatment of reactive oxygen species (ROS)-mediated diseases

Z Chen, CT Vong, C Gao, S Chen, X Wu… - Molecular …, 2020 - ACS Publications
Reactive oxygen species (ROS) are chemically reactive species that are produced in
cellular aerobic metabolism. They mainly include superoxide anion, hydrogen peroxide …

Therapeutic application and construction of bilirubin incorporated nanoparticles

Q Yao, R Chen, V Ganapathy, L Kou - Journal of controlled release, 2020 - Elsevier
Bilirubin is a yellow-colored metabolite of heme degradation (a bile pigment), once believed
to be toxic, but recently recognized as a powerful endogenous antioxidant of physiologic …

Opsonized nanoparticles target and regulate macrophage polarization for osteoarthritis therapy: A trapping strategy

L Kou, H Huang, Y Tang, M Sun, Y Li, J Wu… - Journal of Controlled …, 2022 - Elsevier
Osteoarthritis (OA) is a chronic disease caused by joint inflammation. Its occurrence and
development depend on a continuous inflammation environment. The activated M1 …

[HTML][HTML] Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing

Q Yao, QH Lan, X Jiang, CC Du, YY Zhai, X Shen… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Photothermal therapy employs the photoabsorbers to generate heat under the
near-infrared (NIR) irradiation for thermal tumor ablation. However, NIR irradiation might …

Dual-targeting celecoxib nanoparticles protect intestinal epithelium and regulate macrophage polarization for ulcerative colitis treatment

R Chen, X Lin, Q Wang, X An, X Zhao, Y Lin… - Chemical Engineering …, 2023 - Elsevier
Ulcerative colitis (UC) is a chronic recurrent disease of the gastrointestinal tract. Though the
exact etiology is still unknown, inflamed enterocytes, activated macrophages, and the …

Protective effects and mechanisms of bilirubin nanomedicine against acute pancreatitis

Q Yao, X Jiang, YY Zhai, LZ Luo, HL Xu, J Xiao… - Journal of controlled …, 2020 - Elsevier
Acute pancreatitis (AP) is a sudden inflammatory reaction, caused by the activation of
pancreatic enzymes in the pancreas, and in severe cases can lead to systemic inflammation …

Immune-protective formulations and process strategies for improved survival and function of transplanted islets

Y Shi, YZ Zhao, Z Jiang, Z Wang, Q Wang… - Frontiers in …, 2022 - frontiersin.org
Type 1 diabetes (T1D) is an autoimmune disease caused by the immune system attacking
and destroying insulin-producing β cells in the pancreas. Islet transplantation is becoming …

A Biomimetic Nanoparticle Exerting Protection Against Acute Liver Failure by Suppressing CYP2E1 Activity and Scavenging Excessive ROS

Q Yao, Y Tang, S Dai, L Huang, Z Jiang… - Advanced …, 2023 - Wiley Online Library
Acute liver failure (ALF) is a severe liver disease caused by many reasons. One of them is
the overdosed acetaminophen (APAP), which is metabolized into N‐acetyl‐p‐benzoquinone …

Subcutaneous device-free islet transplantation

X Zhou, Z Xu, Y You, W Yang, BZ Feng… - Frontiers in …, 2023 - frontiersin.org
Diabetes mellitus is a chronic metabolic disease, characterized by high blood sugar levels; it
affects more than 500 million individuals worldwide. Type 1 diabetes mellitus (T1DM) is …

Localized controlled release of bilirubin from β-cyclodextrin-conjugated ε-polylysine to attenuate oxidative stress and inflammation in transplanted islets

Q Yao, ZW Huang, YY Zhai, M Yue… - … applied materials & …, 2020 - ACS Publications
Islet transplantation has been considered the most promising therapeutic option with the
potential to restore the physiological regulation of blood glucose concentrations in type 1 …