Bilirubin nanomedicines for the treatment of reactive oxygen species (ROS)-mediated diseases
Z Chen, CT Vong, C Gao, S Chen, X Wu… - Molecular …, 2020 - ACS Publications
Reactive oxygen species (ROS) are chemically reactive species that are produced in
cellular aerobic metabolism. They mainly include superoxide anion, hydrogen peroxide …
cellular aerobic metabolism. They mainly include superoxide anion, hydrogen peroxide …
Therapeutic application and construction of bilirubin incorporated nanoparticles
Bilirubin is a yellow-colored metabolite of heme degradation (a bile pigment), once believed
to be toxic, but recently recognized as a powerful endogenous antioxidant of physiologic …
to be toxic, but recently recognized as a powerful endogenous antioxidant of physiologic …
Opsonized nanoparticles target and regulate macrophage polarization for osteoarthritis therapy: A trapping strategy
L Kou, H Huang, Y Tang, M Sun, Y Li, J Wu… - Journal of Controlled …, 2022 - Elsevier
Osteoarthritis (OA) is a chronic disease caused by joint inflammation. Its occurrence and
development depend on a continuous inflammation environment. The activated M1 …
development depend on a continuous inflammation environment. The activated M1 …
[HTML][HTML] Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing
Rationale: Photothermal therapy employs the photoabsorbers to generate heat under the
near-infrared (NIR) irradiation for thermal tumor ablation. However, NIR irradiation might …
near-infrared (NIR) irradiation for thermal tumor ablation. However, NIR irradiation might …
Dual-targeting celecoxib nanoparticles protect intestinal epithelium and regulate macrophage polarization for ulcerative colitis treatment
R Chen, X Lin, Q Wang, X An, X Zhao, Y Lin… - Chemical Engineering …, 2023 - Elsevier
Ulcerative colitis (UC) is a chronic recurrent disease of the gastrointestinal tract. Though the
exact etiology is still unknown, inflamed enterocytes, activated macrophages, and the …
exact etiology is still unknown, inflamed enterocytes, activated macrophages, and the …
Protective effects and mechanisms of bilirubin nanomedicine against acute pancreatitis
Acute pancreatitis (AP) is a sudden inflammatory reaction, caused by the activation of
pancreatic enzymes in the pancreas, and in severe cases can lead to systemic inflammation …
pancreatic enzymes in the pancreas, and in severe cases can lead to systemic inflammation …
Immune-protective formulations and process strategies for improved survival and function of transplanted islets
Y Shi, YZ Zhao, Z Jiang, Z Wang, Q Wang… - Frontiers in …, 2022 - frontiersin.org
Type 1 diabetes (T1D) is an autoimmune disease caused by the immune system attacking
and destroying insulin-producing β cells in the pancreas. Islet transplantation is becoming …
and destroying insulin-producing β cells in the pancreas. Islet transplantation is becoming …
A Biomimetic Nanoparticle Exerting Protection Against Acute Liver Failure by Suppressing CYP2E1 Activity and Scavenging Excessive ROS
Acute liver failure (ALF) is a severe liver disease caused by many reasons. One of them is
the overdosed acetaminophen (APAP), which is metabolized into N‐acetyl‐p‐benzoquinone …
the overdosed acetaminophen (APAP), which is metabolized into N‐acetyl‐p‐benzoquinone …
Subcutaneous device-free islet transplantation
X Zhou, Z Xu, Y You, W Yang, BZ Feng… - Frontiers in …, 2023 - frontiersin.org
Diabetes mellitus is a chronic metabolic disease, characterized by high blood sugar levels; it
affects more than 500 million individuals worldwide. Type 1 diabetes mellitus (T1DM) is …
affects more than 500 million individuals worldwide. Type 1 diabetes mellitus (T1DM) is …
Localized controlled release of bilirubin from β-cyclodextrin-conjugated ε-polylysine to attenuate oxidative stress and inflammation in transplanted islets
Islet transplantation has been considered the most promising therapeutic option with the
potential to restore the physiological regulation of blood glucose concentrations in type 1 …
potential to restore the physiological regulation of blood glucose concentrations in type 1 …