ABCD2 is abundant in adipose tissue and opposes the accumulation of dietary erucic acid (C22: 1) in fat [S]
The ATP binding cassette transporter, ABCD2 (D2), is a peroxisomal protein whose mRNA
has been detected in the adrenal, brain, liver, and fat. Although the role of this transporter in …
has been detected in the adrenal, brain, liver, and fat. Although the role of this transporter in …
Caffeic acid phenethyl ester induces adrenoleukodystrophy (Abcd2) gene in human X-ALD fibroblasts and inhibits the proinflammatory response in Abcd1/2 silenced …
X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder caused by mutations in
the ABCD1 gene. Accumulation of very long chain fatty acids (VLCFA) that have been …
the ABCD1 gene. Accumulation of very long chain fatty acids (VLCFA) that have been …
Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy
Oxidative stress and mitochondrial failure are prominent factors in the axonal degeneration
process. In this study, we demonstrate that sirtuin 1 (SIRT1), a key regulator of the …
process. In this study, we demonstrate that sirtuin 1 (SIRT1), a key regulator of the …
Molecular Responses of the Eukaryotic Cell Line INT407 on the Internalized Campylobacter jejuni—The Other Side of the Coin
Campylobacter jejuni is a zoonotic bacterium with the capacity to invade the epithelial cells
during the pathogenic process. Several bacterial factors have been identified to contribute to …
during the pathogenic process. Several bacterial factors have been identified to contribute to …
Predictive structure and topology of peroxisomal ATP-binding cassette (ABC) transporters
P Andreoletti, Q Raas, C Gondcaille… - International journal of …, 2017 - mdpi.com
The peroxisomal ATP-binding Cassette (ABC) transporters, which are called ABCD1,
ABCD2 and ABCD3, are transmembrane proteins involved in the transport of various lipids …
ABCD2 and ABCD3, are transmembrane proteins involved in the transport of various lipids …
Myelin lesions associated with lysosomal and peroxisomal disorders
PL Faust, EM Kaye, JM Powers - Expert review of …, 2010 - Taylor & Francis
Abnormalities of myelin are common in lysosomal and peroxisomal disorders. Most display
a primary loss of myelin in which the myelin sheath and/or oligodendrocytes are selectively …
a primary loss of myelin in which the myelin sheath and/or oligodendrocytes are selectively …
The absence of ABCD2 sensitizes mice to disruptions in lipid metabolism by dietary erucic acid [S]
ABCD2 (D2) is a peroxisomal transporter that is highly abundant in adipose tissue and
promotes the oxidation of long-chain MUFA. Erucic acid (EA, 22: 1ω9) reduces very long …
promotes the oxidation of long-chain MUFA. Erucic acid (EA, 22: 1ω9) reduces very long …
How to move an amphipathic molecule across a lipid bilayer: different mechanisms for different ABC transporters?
FL Theodoulou, DJ Carrier… - Biochemical Society …, 2016 - portlandpress.com
Import of β-oxidation substrates into peroxisomes is mediated by ATP binding cassette
(ABC) transporters belonging to subfamily D. In order to enter the β-oxidation pathway, fatty …
(ABC) transporters belonging to subfamily D. In order to enter the β-oxidation pathway, fatty …
Very long chain fatty acid β-oxidation in astrocytes: contribution of the ABCD1-dependent and-independent pathways
M Morita, S Shinbo, A Asahi… - Biological and …, 2012 - jstage.jst.go.jp
MATERIALS AND METHODS Materials [1-14C] Lignoceric acid (53 mCi/mmol) and [1-14C]
palmitic acid (53 mCi/mmol) were purchased from Moravek Biochemicals (Brea, CA, USA) …
palmitic acid (53 mCi/mmol) were purchased from Moravek Biochemicals (Brea, CA, USA) …
Histone deacetylase inhibitor upregulates peroxisomal fatty acid oxidation and inhibits apoptotic cell death in abcd1-deficient glial cells
In X-ALD, mutation/deletion of ALD gene (ABCD1) and the resultant very long chain fatty
acid (VLCFA) derangement has dramatically opposing effects in astrocytes and …
acid (VLCFA) derangement has dramatically opposing effects in astrocytes and …