Loss of the AE3 Cl−/HCO3− exchanger (Slc4a3) in mice causes an impaired cardiac force-
frequency response and heart failure under some conditions but the mechanisms are not …

The dysfunction of ABCD1, a peroxisomal ABC protein, leads to the perturbation of very long
chain fatty acid (VLCFA) metabolism and is the cause of X-linked adrenoleukodystrophy …

Campylobacter jejuni is a zoonotic bacterium, causing intestinal infection in humans. One
characteristic feature of the pathogenicity process is the ability of this bacterium invading the …

Peroxisomes are organelles that are essential for maintaining cellular function in lipid
metabolism, redox homeostasis and intracellular signalling. They are involved in the β …

Metabolism is controlled to ensure organismal development and homeostasis. Several
mechanisms regulate metabolism, including allosteric control and transcriptional regulation …

Metachromatic leukodystrophy (MLD) and adrenoleukodystrophy (ALD) are two inherited
leukodystrophies that result in most cases in rapid destruction of the myelin within the central …

In the current version of the International Statistical Classification of Diseases and Related
Health Problems, 10th Revision (ICD-10), subsection F (Classification of Mental and …

Canine atopic dermatitis (CAD) is a multifactorial disease including genetic predisposition
and other predisposing factors like living environment and diet. There is no known cure for …

A thesis submitted in total fulfilment of the requirements for the degree of Doctor of
Philosophy to the Department of Physiology, Anatomy and Microbiology, School of Life …

Abstract (DE) Die X-chromosomale vererbte Adrenoleukodystrophie gehört zu den
häufigsten monogenetischen, neurodegenerativen Erkrankungen im Kindes-, und …