Alzheimer disease is the most prevalent form of dementia globally and is characterized
premortem by a gradual memory loss and deterioration of higher cognitive functions and …

Aggregation of amyloid-β (Aβ) as toxic oligomers and amyloid plaques within the brain
appears to be the pathogenic event that initiates Alzheimer's disease (AD) lesions. One …

NMDA receptor (NMDAR) dysfunction has emerged as a common theme in several major
nervous system disorders, including ischemic brain injury, chronic neurodegenerative …

Amyloid beta peptide (Aβ), the main component of senile plaques of Alzheimer's disease
brains, is produced by sequential cleavage of amyloid precursor protein (APP) and of its C …

The key role of APP in the pathogenesis of Alzheimer disease is well established. However,
postnatal lethality of double knockout mice has so far precluded the analysis of the …

Alzheimer's disease (AD) is a common age-related neurodegenerative disease
characterized by progressive cognitive decline and irreversible memory impairment …

Alzheimer's disease (AD) is characterized by synaptic failure, dendritic and axonal atrophy,
neuronal death and progressive loss of cognitive functions. It is commonly assumed that …

Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …

Abstract Alzheimer's disease (AD), the most prevalent neurodegenerative disease in the
elderly population, is characterized by progressive cognitive decline and pathological …

Calcium is a key mediator controlling essential neuronal functions depending on electrical
activity. Altered neuronal calcium homeostasis affects metabolism of amyloid precursor …