Arginine (L-arginine), is an amino acid involved in a number of biological processes,
including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide …

Background: The primary objective of this review was to explore the contribution of oxidative
stress to the pathogenesis of genetically-triggered thoracic aortic aneurysm (TAA) …

Thoracic aortic aneurysm, as occurs in Marfan syndrome, is generally asymptomatic until
dissection or rupture, requiring surgical intervention as the only available treatment. Here …

Patients with Marfan syndrome (MFS) develop thoracic aortic aneurysms as the aorta
presents excessive elastin breaks, fibrosis, and vascular smooth muscle cell (vSMC) death …

Recent studies have shown that NO is a central mediator in diseases associated with
thoracic aortic aneurysm, such as Marfan syndrome. The progressive dilation of the aorta in …

Cardiovascular disease (CVD) is closely related to chronic kidney disease (CKD), and
patients with CKD have a high risk of CVD-related mortality. Traditional CVD risk factors …

Background Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in
the Fibrillin-1 gene (FBN1). Here, we undertook the first epigenome-wide association study …

Marfan syndrome (MFS) patients are at risk for cardiovascular disease. In particular, for
aortic aneurysm formation, which ultimately can result in a life-threatening aortic dissection …

Cardiovascular disease (CVD), as a possible consequence of endothelial dysfunction, is
prevalent among HIV-infected patients despite successful administration of antiretroviral …

Background Aortic root ectasia might induce hemostatic disorders in patients with Marfan
syndrome (MFS) via altered blood flow and rheology. The aim of this study was to explore …