Increased risky choice during forced abstinence from fentanyl on the cued rat gambling task

KM Hrelja, C Kawkab, DK Avramidis, S Ramaiah… - …, 2024 - Springer
Rationale The use of illicit opioids has arguably never been more risky; street drug potency
can be dangerously high, is often unknown to the consumer, and results in multiple daily …

Methamphetamine increases risky choice in rats, but only when magnitude and probability of reinforcement are manipulated within a session

JR Yates, S Adhikari, RE Bako, KL Berling… - Pharmacology …, 2024 - Elsevier
Risky choice is associated with maladaptive behaviors, particularly substance use disorders.
Current animal models of risky choice are often confounded by other constructs like …

[HTML][HTML] Effects of systemic oxytocin receptor activation and blockade on risky decision making in female and male rats

M Faraji, OA Viera-Resto, BJ Berrios, JL Bizon… - bioRxiv, 2024 - ncbi.nlm.nih.gov
The neuropeptide oxytocin is traditionally known for its roles in parturition, lactation, and
social behavior. Other data, however, show that oxytocin can modulate behaviors outside of …

[HTML][HTML] Neural signatures of opioid-induced risk-taking behavior in the prelimbic prefrontal cortex

CB Quave, AM Vasquez, G Aquino-Miranda, EP Bora… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Opioid use disorder occurs alongside impaired risk-related decision-making, but the
underlying neural correlates are unclear. We developed a novel approach-avoidance …

Escalation of intravenous fentanyl self-administration and assessment of withdrawal behavior in male and female mice

Y Chen, T Xiao, A Kimbrough - bioRxiv, 2024 - biorxiv.org
Background: The rise in overdose deaths from synthetic opioids, especially fentanyl,
necessitates the development of preclinical models to study fentanyl use disorder (FUD) …

Towards a better understanding of the bidirectional relationship between decision-making and addiction vulnerability

KM Hrelja - 2024 - open.library.ubc.ca
Impaired decision-making is recognized as a diagnostic criterion for many different
psychiatric disorders including gambling disorder and substance use disorders. Habit …