[HTML][HTML] Tackling the emerging threat of antifungal resistance to human health
Invasive fungal infections pose an important threat to public health and are an under-
recognized component of antimicrobial resistance, an emerging crisis worldwide. Across a …
recognized component of antimicrobial resistance, an emerging crisis worldwide. Across a …
[HTML][HTML] Treatment strategies for cryptococcal infection: challenges, advances and future outlook
Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …
[HTML][HTML] Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens
E Ksiezopolska, T Gabaldón - Genes, 2018 - mdpi.com
Fungal infections, such as candidiasis caused by Candida, pose a problem of growing
medical concern. In developed countries, the incidence of Candida infections is increasing …
medical concern. In developed countries, the incidence of Candida infections is increasing …
Genome-wide analysis of experimentally evolved Candida auris reveals multiple novel mechanisms of multidrug resistance
Candida auris is globally recognized as an opportunistic fungal pathogen of high concern,
due to its extensive multidrug resistance (MDR). Still, molecular mechanisms of MDR are …
due to its extensive multidrug resistance (MDR). Still, molecular mechanisms of MDR are …
New pathogens, new tricks: emerging, drug‐resistant fungal pathogens and future prospects for antifungal therapeutics
J Geddes‐McAlister, RS Shapiro - … of the New York Academy of …, 2019 - Wiley Online Library
Fungal pathogens are a growing threat to public health. As human immunodeficiency
becomes increasingly common, fungal infections are becoming more prevalent. The use of …
becomes increasingly common, fungal infections are becoming more prevalent. The use of …
Exploring future applications of the apiculate yeast Hanseniaspora
As a metaphor, lemons get a bad rap; however the proverb 'if life gives you lemons, make
lemonade'is often used in a motivational context. The same could be said of Hanseniaspora …
lemonade'is often used in a motivational context. The same could be said of Hanseniaspora …
[HTML][HTML] Extensive loss of cell-cycle and DNA repair genes in an ancient lineage of bipolar budding yeasts
Cell-cycle checkpoints and DNA repair processes protect organisms from potentially lethal
mutational damage. Compared to other budding yeasts in the subphylum …
mutational damage. Compared to other budding yeasts in the subphylum …
[HTML][HTML] 5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus
RB Billmyre, S Applen Clancey, LX Li… - Nature …, 2020 - nature.com
Patients infected with the fungal pathogen Cryptococcus are most effectively treated with a
combination of 5-fluorocytosine (5FC) and amphotericin B. 5FC acts as a prodrug, which is …
combination of 5-fluorocytosine (5FC) and amphotericin B. 5FC acts as a prodrug, which is …
[HTML][HTML] Facilitators of adaptation and antifungal resistance mechanisms in clinically relevant fungi
MWJ Hokken, BJ Zwaan, WJG Melchers… - Fungal genetics and …, 2019 - Elsevier
Opportunistic fungal pathogens can cause a diverse range of diseases in humans. The
increasing rate of fungal infections caused by strains that are resistant to commonly used …
increasing rate of fungal infections caused by strains that are resistant to commonly used …
Mechanisms of triazole resistance in Aspergillus fumigatus
The ubiquitous fungal pathogen Aspergillus fumigatus is the primary cause of opportunistic
mould infections in humans. Aspergilli disseminate via asexual conidia passively travelling …
mould infections in humans. Aspergilli disseminate via asexual conidia passively travelling …