[HTML][HTML] Vulnerability and resilience to Alzheimer's disease: early life conditions modulate neuropathology and determine cognitive reserve
SL Lesuis, L Hoeijmakers, A Korosi… - … research & therapy, 2018 - alzres.biomedcentral.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a high
prevalence among the elderly and a huge personal and societal impact. Recent …
prevalence among the elderly and a huge personal and societal impact. Recent …
[HTML][HTML] Sexual dimorphism in the 3xTg-AD mouse model and its impact on pre-clinical research
JL Dennison, NR Ricciardi, I Lohse… - Journal of …, 2021 - content.iospress.com
Female sex is a leading risk factor for developing Alzheimer's disease (AD). Sexual
dimorphism in AD is gaining attention as clinical data show that women are not only more …
dimorphism in AD is gaining attention as clinical data show that women are not only more …
[HTML][HTML] Vitamin D improves neurogenesis and cognition in a mouse model of Alzheimer's disease
M Morello, V Landel, E Lacassagne, K Baranger… - Molecular …, 2018 - Springer
The impairment of hippocampal neurogenesis at the early stages of Alzheimer's disease
(AD) is believed to support early cognitive decline. Converging studies sustain the idea that …
(AD) is believed to support early cognitive decline. Converging studies sustain the idea that …
[HTML][HTML] Impact of social isolation on the behavioral, functional profiles, and hippocampal atrophy asymmetry in dementia in times of coronavirus pandemic (COVID-19 …
A Muntsant, L Giménez-Llort - Frontiers in psychiatry, 2020 - frontiersin.org
The impact of COVID-19 on the elderly is devastating, and nursing homes are struggling to
provide the best care to the most fragile. The urgency and severity of the pandemic forces …
provide the best care to the most fragile. The urgency and severity of the pandemic forces …
Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease
Alzheimer's disease (AD) begins with a deficit of synaptic function and adenosine A 2A
receptors (A 2A R) are mostly located in synapses controlling synaptic plasticity. The over …
receptors (A 2A R) are mostly located in synapses controlling synaptic plasticity. The over …
[HTML][HTML] Dopaminergic dysfunction in the 3xTg-AD mice model of Alzheimer's disease
Y Gloria, K Ceyzériat, S Tsartsalis, P Millet… - Scientific reports, 2021 - nature.com
Alzheimer's disease (AD) is characterized by amyloid (Aβ) protein aggregation and
neurofibrillary tangles accumulation, accompanied by neuroinflammation. With all the …
neurofibrillary tangles accumulation, accompanied by neuroinflammation. With all the …
Sex-dependent end-of-life mental and vascular scenarios for compensatory mechanisms in mice with normal and ad-neurodegenerative aging
A Muntsant, F Jiménez-Altayó, L Puertas-Umbert… - Biomedicines, 2021 - mdpi.com
Life expectancy decreases with aging, with cardiovascular, mental health, and
neurodegenerative disorders strongly contributing to the total disability-adjusted life years …
neurodegenerative disorders strongly contributing to the total disability-adjusted life years …
Theta and gamma oscillatory dynamics in mouse models of Alzheimer's disease: A path to prospective therapeutic intervention
SF Mehak, AB Shivakumar, S Kumari… - Neuroscience & …, 2022 - Elsevier
Understanding the neural basis of cognitive deficits, a key feature of Alzheimer's disease
(AD), is imperative for achieving the therapy of the disease. Rhythmic oscillatory activities in …
(AD), is imperative for achieving the therapy of the disease. Rhythmic oscillatory activities in …
[HTML][HTML] A preclinical perspective on the enhanced vulnerability to Alzheimer's disease after early-life stress
L Hoeijmakers, SL Lesuis, H Krugers, PJ Lucassen… - Neurobiology of …, 2018 - Elsevier
Stress experienced early in life (ES), in the form of childhood maltreatment, maternal neglect
or trauma, enhances the risk for cognitive decline in later life. Several epidemiological …
or trauma, enhances the risk for cognitive decline in later life. Several epidemiological …
Water and T-maze protocols are equally efficient methods to assess spatial memory in 3xTg Alzheimer's disease mice
KE Davis, K Burnett, J Gigg - Behavioural brain research, 2017 - Elsevier
Rodent spatial memory is commonly tested using the water-maze; however, there is a
potential confound of stress on learning in this behavioural paradigm. This is particularly …
potential confound of stress on learning in this behavioural paradigm. This is particularly …