Abstract The US Food and Drug administration (FDA) has approved several polyclonal
antibody preparations and at least 18 monoclonal antibody preparations (antibodies …

Targeted therapies using monoclonal antibodies have achieved important therapeutic
applications in the treatment of various human diseases. Understanding the factors that …

HER2 is a transmembrane oncoprotein encoded by the HER2/neu gene and is
overexpressed in approximately 20 to 25% of invasive breast cancers. It can be …

The MHC class I-like Fc receptor FcRn plays an essential role in extending the half-life (t 1/2)
of IgG antibodies and IgG-Fc-based therapeutics in the circulation. The goal of this study …

2004-11-10 Assigned to XENCOR, INC. reassignment XENCOR, INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DANG, WEI …

N‐Glycans at Asn297 in the Fc domain of IgG molecules are required for Fc receptor‐
mediated effector functions such as antibody‐dependent cell‐mediated cytotoxicity (ADCC) …

Antibodies to cell-surface antigens trigger activatory Fcγ receptor (FcγR)-mediated
retrograde signals in leukocytes to control immune effector functions. Here, we uncover an …

2005-09-29 Assigned to XENCOR, INC. reassignment XENCOR, INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HAYES, ROBERT …

Abstract Development of monoclonal antibodies (mAbs) and their functional derivatives
represents a growing segment of the development pipeline in the pharmaceutical industry …

ABSTRACT Immunotherapy of cancer has been explored for over a century, but it is only in
the last decade that various antibody‐based products have been introduced into the …