Recent studies have demonstrated that cancer-associated adipocytes (CAAs) in the tumor
microenvironment are involved in the malignant progression of breast cancer. However, the …

Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that regulates a plethora of
downstream signaling pathways essential for cell migration, proliferation and death …

Increasing cell mobility is the basis of tumor invasion and metastasis, and is therefore a
therapeutic target for preventing the spread of many types of cancer. Septins are a family of …

Macrophage infiltration in mammary tumors is associated with enhanced tumor progression,
metastasis, and poor clinical outcome, and considered as target for therapeutic intervention …

In the last several years, our appreciation of intra-tumoral heterogeneity has greatly
increased due to accumulating evidence for the co-existence of genetically and …

Focal adhesion kinase (FAK) and Wnt signaling pathways are important contributors to
tumorigenesis in several cancers. While most results come from studies investigating these …

Tenascin-C is an extracellular matrix glycoprotein that plays a critical role in kidney fibrosis
by orchestrating a fibrogenic niche. Here, we demonstrate that tenascin-C is a biomarker …

Analogues structurally related to anaplastic lymphoma kinase (ALK) inhibitor 1 were
optimized for metabolic stability. The results from this endeavor not only led to improved …

Tunneling nanotubes (TnTs) are thin channels that temporally connect nearby cells allowing
the cell-to-cell trafficking of biomolecules and organelles. The presence or absence of TnTs …

In the current work, new 1, 3, 4-oxadiazole derivatives were synthesized and investigated for
their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 …