Adenosine signalling has long been a target for drug development, with adenosine itself or
its derivatives being used clinically since the 1940s. In addition, methylxanthines such as …

Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …

Abstract Pannexin 1 (PANX1) is an ATP-permeable channel with critical roles in a variety of
physiological functions such as blood pressure regulation, apoptotic cell clearance and …

Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Adenosine triphosphate (ATP) has been well established as an important extracellular
ligand of autocrine signaling, intercellular communication, and neurotransmission with …

Adenosine, a nucleoside derived primarily from the extracellular hydrolysis of adenine
nucleotides, is a potent regulator of inflammation. Adenosine mediates its effects on …

Gap junctions are aggregates of intercellular channels that permit direct cell–cell transfer of
ions and small molecules. Initially described as low-resistance ion pathways joining …

This review article provides a historical perspective on the role of purinergic signalling in the
regulation of various subsets of immune cells from early discoveries to current …

Three family members compose the pannexin family of channel-forming glycoproteins
(Panx1, Panx2 and Panx3). Their primary function is defined by their capacity to form single …

The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …