Adenosine receptors as drug targets—what are the challenges?
JF Chen, HK Eltzschig, BB Fredholm - Nature reviews Drug discovery, 2013 - nature.com
Adenosine signalling has long been a target for drug development, with adenosine itself or
its derivatives being used clinically since the 1940s. In addition, methylxanthines such as …
its derivatives being used clinically since the 1940s. In addition, methylxanthines such as …
Connexins in cardiovascular and neurovascular health and disease: pharmacological implications
Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …
hemichannels and as intercellular gap junction channels that directly connect cells. In the …
Structures of human pannexin 1 reveal ion pathways and mechanism of gating
Abstract Pannexin 1 (PANX1) is an ATP-permeable channel with critical roles in a variety of
physiological functions such as blood pressure regulation, apoptotic cell clearance and …
physiological functions such as blood pressure regulation, apoptotic cell clearance and …
[HTML][HTML] Gap junctions
Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …
Adenosine and adenosine receptors in the pathogenesis and treatment of rheumatic diseases
BN Cronstein, M Sitkovsky - Nature Reviews Rheumatology, 2017 - nature.com
Adenosine, a nucleoside derived primarily from the extracellular hydrolysis of adenine
nucleotides, is a potent regulator of inflammation. Adenosine mediates its effects on …
nucleotides, is a potent regulator of inflammation. Adenosine mediates its effects on …
Purinergic signalling and immune cells
G Burnstock, JM Boeynaems - Purinergic signalling, 2014 - Springer
This review article provides a historical perspective on the role of purinergic signalling in the
regulation of various subsets of immune cells from early discoveries to current …
regulation of various subsets of immune cells from early discoveries to current …
Gap junctions
DA Goodenough, DL Paul - Cold Spring Harbor …, 2009 - cshperspectives.cshlp.org
Gap junctions are aggregates of intercellular channels that permit direct cell–cell transfer of
ions and small molecules. Initially described as low-resistance ion pathways joining …
ions and small molecules. Initially described as low-resistance ion pathways joining …
ATP release channels
A Taruno - International journal of molecular sciences, 2018 - mdpi.com
Adenosine triphosphate (ATP) has been well established as an important extracellular
ligand of autocrine signaling, intercellular communication, and neurotransmission with …
ligand of autocrine signaling, intercellular communication, and neurotransmission with …
[HTML][HTML] The biochemistry and function of pannexin channels
Three family members compose the pannexin family of channel-forming glycoproteins
(Panx1, Panx2 and Panx3). Their primary function is defined by their capacity to form single …
(Panx1, Panx2 and Panx3). Their primary function is defined by their capacity to form single …
Intercellular Ca2+ Waves: Mechanisms and Function
L Leybaert, MJ Sanderson - Physiological reviews, 2012 - journals.physiology.org
Intercellular calcium (Ca2+) waves (ICWs) represent the propagation of increases in
intracellular Ca2+ through a syncytium of cells and appear to be a fundamental mechanism …
intracellular Ca2+ through a syncytium of cells and appear to be a fundamental mechanism …