Abstract Connexin 43 (Cx43) hemichannels may form open channels in the plasma
membrane when exposed to specific stimuli, eg reduced extracellular concentration of …

Gap junction communication (GJC) mediated by connexins is critical for heart function. To
gain insight into the causal relationship of molecular mechanisms of disease pathology, it is …

Background: Mutations leading to changes in properties, regulation, or expression of
connexin-made channels have been implicated in 28 distinct human hereditary diseases …

Decades of research have indicated that gap junction channels contribute to the
propagation of apoptosis between neighboring cells. Inositol 1, 4, 5-trisphosphate (IP 3) has …

Diabetic retinopathy is the leading cause of blindness in the working age population.
Unfortunately, there is no cure for this devastating ocular complication. The early stage of …

Prior to the “onset of hearing,” developing cochlear inner hair cells (IHCs) and primary
auditory neurons undergo experience‐independent activity, which is thought to be important …

Although Ca i 2+ waves in networks of astrocytes in vivo are well documented, propagation
in vivo is much more complex than in culture, and there is no consensus concerning the …

Death of murine T cells induced by extracellular ATP is mainly triggered by activation of
purinergic P2X7 receptors (P2X7Rs). However, a link between P2X7Rs and pannexin1 …

The adult zebrafish spinal cord displays an impressive innate ability to regenerate after
traumatic insults, yet the underlying adaptive cellular mechanisms remain elusive. Here, we …

Connexin (Cx) hemichannels (HCs) are large pore hexameric structures that allow the
exchange of ions, metabolites and a variety of other molecules between the cell cytoplasm …