Inherited diseases caused by connexin mutations are found in multiple organs and include
hereditary deafness, congenital cataract, congenital heart diseases, hereditary skin …

Purinergic signaling, a concept originally formulated by the late Geoffrey Burnstock (1929–
2020), was found to modulate pathways in every physiological system. In metabolic …

Mutations in GJB2, the gene that encodes connexin 26 (Cx26), are the most common cause
of sensorineural hearing impairment. The truncating variant 35delG, which determines a …

Noise-induced hearing loss (NIHL) is a major unresolved public health problem. Here, we
investigate pathomechanisms of sensory hair cell death and suggest a novel target for …

Many cellular functions are driven by changes in the intracellular Ca 2+ concentration ([Ca
2+] i) that are highly organized in time and space. Ca 2+ oscillations are particularly …

Given the widespread importance of purinergic receptor-evoked signaling, understanding
how ATP and other nucleotides are released from cells in a regulated manner is an …

Stress affects brain areas involved in learning and emotional responses, which may
contribute in the development of cognitive deficits associated with major depression. These …

Defects in several different connexins have been associated with several different diseases.
The most common of these is deafness, where a few mutations in connexin (Cx) 26 have …

Activation of astrocytes surrounding amyloid plaques is a hallmark of Alzheimer disease
(AD) with consequences yet poorly understood. Astrocytes are characterized by a high level …

Hemichannels (HCs) and gap junction channels (GJCs) formed by protein subunits called
connexins (Cxs) are major pathways for intercellular communication. While HCs connect the …