Connexin mimetic peptides corresponding to short conserved extracellular loop sequences
of connexins have been used widely as reversible inhibitors of gap junctional intercellular …

Neutrophils are the first immune cells to kill invading microbes at sites of infection using a
variety of processes, including the release of proteases, phagocytosis and the production of …

Connexin hemichannels are single membrane channels which have been traditionally
thought to work in pairs to form gap junction channels across two opposing cells. In …

The threshold for bidirectional modification of synaptic plasticity is known to be controlled by
several factors, including the balance between protein phosphorylation and …

Ubiquitously expressed connexins are tetra-spanning transmembrane proteins that form
intercellular gap junction channels or cell surface hemichannels. Connexins share similar …

Mutations in the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin
30 (Cx30) have been linked to syndromic and nonsyndromic hearing loss in mice and …

Hearing loss is the most common congenital sensory impairment. Mutations or deficiencies
of the GJB2 gene are the most common genetic cause of congenital nonsyndromic …

Mutations in Cx26 gene are found in most cases of human genetic deafness. Some
mutations produce syndromic deafness associated with skin disorders, like the Keratitis …

It is widely recognized that ATP, along with other nucleotides, subserves important
intercellular signalling processes. Among various nucleotide release mechanisms, the …

Cardiac fibroblasts (CFs) play an essential role in remodeling of the cardiac extracellular
matrix. Extracellular nucleotide signaling may provoke a profibrotic response in CFs. We …