Intrinsically generated neural activity propagates through the developing auditory system to
promote maturation and refinement of sound processing circuits prior to hearing onset. This …

Outer hair cells (OHCs) are highly specialized sensory cells conferring the fine‐tuning and
high sensitivity of the mammalian cochlea to acoustic stimuli. Here, by genetically …

Organization of immune responses requires exchange of information between cells. This is
achieved through either direct cell–cell contacts and establishment of temporary synapses …

The X-linked demyelinating/type I Charcot-Marie-Tooth neuropathy (CMT1X) is an inherited
peripheral neuropathy caused by mutations in GJB1, the gene that encodes the gap junction …

In hearing, mechanically sensitive hair cells (HCs) in the cochlea release glutamate onto
spiral ganglion neurons (SGNs) to relay auditory information to the central nervous system …

Hemichannels, which are one half of the gap junction channels, have independent
physiological roles. Although hemichannels consisting of connexins are more widely …

Mutation of the GJB2 gene, which encodes the connexin 26 (Cx26) gap junction (GJ)
protein, is the most common cause of hereditary, sensorineural hearing loss. Cx26 is not …

Ca2+ is known as a universal messenger mediating a wide variety of cellular processes,
including cell death. In fact, this ion has been proposed as the 'cell death master', not only at …

Pannexin-1 (Panx1) hemichannel is a non-selective transmembrane channel that may play
important roles in intercellular signaling by allowing the permeation of ions and metabolites …

Spatially and temporally coordinated variations of the cytosolic free calcium concentration
([Ca2+] c) play a crucial role in a variety of tissues. In the developing sensory epithelium of …