ABC transporters: human disease and pharmacotherapeutic potential

JM Moore, EL Bell, RO Hughes, AS Garfield - Trends in Molecular …, 2023 - cell.com
Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are a 48-member
superfamily of membrane proteins that actively transport a variety of biological substrates …

Membrane transporters in drug development and as determinants of precision medicine

A Galetin, KLR Brouwer, D Tweedie… - Nature Reviews Drug …, 2024 - nature.com
The effect of membrane transporters on drug disposition, efficacy and safety is now well
recognized. Since the initial publication from the International Transporter Consortium …

Natural products as a tool to modulate the activity and expression of multidrug resistance proteins of intestinal barrier

C Martins-Gomes, AM Silva - Journal of Xenobiotics, 2023 - mdpi.com
The role of intestinal barrier homeostasis in an individual's general well-being has been
widely addressed by the scientific community. Colorectal cancer is among the illnesses that …

W546 stacking disruption traps the human porphyrin transporter ABCB6 in an outward-facing transient state

SS Lee, JG Park, E Jang, SH Choi, S Kim… - Communications …, 2023 - nature.com
Human ATP-binding cassette transporter subfamily B6 (ABCB6) is a mitochondrial ATP-
driven pump that translocates porphyrins from the cytoplasm into mitochondria for heme …

Metagenomics of virus diversities in solid-state brewing process of traditional Chinese vinegar

Z Yu, Y Ma, Y Guan, Y Zhu, K Wang, Y Wang, P Liu… - Foods, 2022 - mdpi.com
Traditional Chinese vinegar offers an exceptional flavor and rich nutrients due to its unique
solid-state fermentation process, which is a multiple microbial fermentation system including …

[HTML][HTML] Protective effect of ginseng seed oil nanoemulsion against human coronavirus OC43 through modulation of ABCG transporters

S Dhandapania, R Wang, A Samad, THM Tran… - Journal of Functional …, 2024 - Elsevier
Recent studies have highlighted the potential of unsaturated fatty acids in natural oils to
influence virus replication. This study extracted ginseng seed oil (GSO) and evaluated its …

Assimilation of phthalate esters in bacteria

P Qiao, T Ying, M Gu, J Zhu, C Mei, T Hu, T Liu… - Applied Microbiology …, 2024 - Springer
The massive usage of phthalate esters (PAEs) has caused serious pollution. Bacterial
degradation is a potential strategy to remove PAE contamination. So far, an increasing …

Protein structure and dynamics in the era of integrative structural biology

R Grandori - Frontiers in Biophysics, 2023 - frontiersin.org
Proteins carry out their biological activity as dynamic structures and populate in solution or in
biological membranes structural distributions with different degrees of heterogeneity. The …