ABC transporters: human disease and pharmacotherapeutic potential
Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are a 48-member
superfamily of membrane proteins that actively transport a variety of biological substrates …
superfamily of membrane proteins that actively transport a variety of biological substrates …
Membrane transporters in drug development and as determinants of precision medicine
A Galetin, KLR Brouwer, D Tweedie… - Nature Reviews Drug …, 2024 - nature.com
The effect of membrane transporters on drug disposition, efficacy and safety is now well
recognized. Since the initial publication from the International Transporter Consortium …
recognized. Since the initial publication from the International Transporter Consortium …
Natural products as a tool to modulate the activity and expression of multidrug resistance proteins of intestinal barrier
C Martins-Gomes, AM Silva - Journal of Xenobiotics, 2023 - mdpi.com
The role of intestinal barrier homeostasis in an individual's general well-being has been
widely addressed by the scientific community. Colorectal cancer is among the illnesses that …
widely addressed by the scientific community. Colorectal cancer is among the illnesses that …
W546 stacking disruption traps the human porphyrin transporter ABCB6 in an outward-facing transient state
SS Lee, JG Park, E Jang, SH Choi, S Kim… - Communications …, 2023 - nature.com
Human ATP-binding cassette transporter subfamily B6 (ABCB6) is a mitochondrial ATP-
driven pump that translocates porphyrins from the cytoplasm into mitochondria for heme …
driven pump that translocates porphyrins from the cytoplasm into mitochondria for heme …
Metagenomics of virus diversities in solid-state brewing process of traditional Chinese vinegar
Z Yu, Y Ma, Y Guan, Y Zhu, K Wang, Y Wang, P Liu… - Foods, 2022 - mdpi.com
Traditional Chinese vinegar offers an exceptional flavor and rich nutrients due to its unique
solid-state fermentation process, which is a multiple microbial fermentation system including …
solid-state fermentation process, which is a multiple microbial fermentation system including …
[HTML][HTML] Protective effect of ginseng seed oil nanoemulsion against human coronavirus OC43 through modulation of ABCG transporters
Recent studies have highlighted the potential of unsaturated fatty acids in natural oils to
influence virus replication. This study extracted ginseng seed oil (GSO) and evaluated its …
influence virus replication. This study extracted ginseng seed oil (GSO) and evaluated its …
Assimilation of phthalate esters in bacteria
P Qiao, T Ying, M Gu, J Zhu, C Mei, T Hu, T Liu… - Applied Microbiology …, 2024 - Springer
The massive usage of phthalate esters (PAEs) has caused serious pollution. Bacterial
degradation is a potential strategy to remove PAE contamination. So far, an increasing …
degradation is a potential strategy to remove PAE contamination. So far, an increasing …
Protein structure and dynamics in the era of integrative structural biology
R Grandori - Frontiers in Biophysics, 2023 - frontiersin.org
Proteins carry out their biological activity as dynamic structures and populate in solution or in
biological membranes structural distributions with different degrees of heterogeneity. The …
biological membranes structural distributions with different degrees of heterogeneity. The …
Special issue Transporter and Channel
D Deng - Proteins, 2022 - pubmed.ncbi.nlm.nih.gov