Antimitotic agents have generated considerable interest among cytotoxic agents due to the
tremendous success of the taxanes and the widespread use of the Vinca alkaloids in clinical …

We synthesized thirty-six novel pyrazole derivatives and studied their antiproliferative activity
in human ovarian adenocarcinoma A2780 cells, human lung carcinoma A549 cells, and …

We present a method for testing many biological mechanisms in cellular assays using an
annotated library of 2036 small organic molecules. This annotated compound library …

A new class of pyrazole and isoxazole conjugates were synthesized and evaluated for their
cytotoxic activity against various human cancer cell lines. These compounds have shown …

Breast cancer (BCA) represents the highest incidence of death in 35-to 60-year-old women.
Above all, hormone unresponsive BCA is still associated with poorer prognosis than …

Pyrimidinyl pyrazole derivatives 1–4, prepared as a new scaffold of an anti-tumor agent,
showed antiproliferative activity against human lung cancer cell lines and inhibited tubulin …

Metal complexes 1–9 have been synthesized by reacting the benzothiazole–pyrazole
derivative ligands (L1, L2 and L3) with the metal precursors of ruthenium (Ru), rhodium (Rh) …

A series of novel 3-substituted-1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-1-trans-propenes in
order to improve the in vitro and in vivo activity of our prototype 3-[4-(3-chlorophenyl)-1 …

A series of novel 3-[4-phenyl-1-piperazinyl]-1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-1-trans-
propenes and related compounds were synthesized and evaluated by their cytotoxic activity …

The invention provides a method of treating or inhibiting the growth of cancerous tumor cells
and associated diseases in a mammal in need thereof which comprises administering to …