The increase in global lifespan has in turn increased the prevalence of osteoarthritis which
is now the most common type of arthritis. Cartilage tissue located on articular joints erodes …

Chronic, low-grade inflammation in osteoarthritis (OA) contributes to symptoms and disease
progression. Effective disease-modifying OA therapies are lacking, but better understanding …

Apoptosis of chondrocytes are the main initiator of osteoarthritis (OA) and can be explained
by oxidative stress and endoplasmic reticulum (ER) stress, thus the pharmacological …

Understanding the molecular mechanisms regulating the maintenance and destruction of
intervertebral disc may lead to the development of new therapies for intervertebral disc …

Osteoarthritis is a common joint disease for which there are currently no disease-modifying
drugs available. Degradation of the cartilage extracellular matrix is a central feature of the …

Osteoarthritis (OA) was once defined as a non-inflammatory arthropathy, but it is now well-
recognized that there is a major inflammatory component to this disease. In addition to …

Objectives Osteoarthritis is associated with cell death and extracellular matrix degradation in
articular cartilage. Autophagy is an essential cellular homeostasis mechanism that was …

Osteoarthritis (OA) is the most common degenerative joint disease that causes painful
swelling and permanent damage to the joints in the body. The molecular mechanisms of OA …

During aging and after traumatic injuries, cartilage and bone cells are exposed to various
pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated …

Cell death in skeletal component cells, including chondrocytes, osteoblasts, and osteocytes,
plays roles in skeletal development, maintenance, and repair as well as in the pathogenesis …