Pulmonary arteriovenous malformations

CL Shovlin - American journal of respiratory and critical care …, 2014 - atsjournals.org
Within the past decade, pulmonary arteriovenous malformations (PAVMs) have evolved from
rare curiosities to not uncommon clinical states, with the latest estimates suggesting a …

Pulmonary vascular complications in hereditary hemorrhagic telangiectasia and the underlying pathophysiology

S Bofarid, AE Hosman, JJ Mager, RJ Snijder… - International journal of …, 2021 - mdpi.com
In this review, we discuss the role of transforming growth factor-beta (TGF-β) in the
development of pulmonary vascular disease (PVD), both pulmonary arteriovenous …

British Thoracic Society clinical statement on pulmonary arteriovenous malformations

CL Shovlin, R Condliffe, JW Donaldson, DG Kiely… - Thorax, 2017 - thorax.bmj.com
Pulmonary arteriovenous malformations (PAVMs) are structurally abnormal vascular
communications that provide a continuous right-to-left shunt between pulmonary arteries …

Low serum iron levels are associated with elevated plasma levels of coagulation factor VIII and pulmonary emboli/deep venous thromboses in replicate cohorts of …

JA Livesey, RA Manning, JH Meek, JE Jackson… - Thorax, 2012 - thorax.bmj.com
Background Elevated plasma levels of coagulation factor VIII are a strong risk factor for
pulmonary emboli and deep venous thromboses. Objectives To identify reversible …

The lung in hereditary hemorrhagic telangiectasia

S Dupuis-Girod, V Cottin, CL Shovlin - Respiration, 2017 - karger.com
Hereditary hemorrhagic telangiectasia (HHT) is a dominantly inherited genetic vascular
disorder with an estimated prevalence of 1 in 6,000, characterized by recurrent epistaxis …

Ischaemic strokes in patients with pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia: associations with iron deficiency and platelets

CL Shovlin, B Chamali, V Santhirapala, JA Livesey… - PLoS …, 2014 - journals.plos.org
Background Pulmonary first pass filtration of particles marginally exceeding∼ 7 µm (the size
of a red blood cell) is used routinely in diagnostics, and allows cellular aggregates forming …

Arterial oxygen content is precisely maintained by graded erythrocytotic responses in settings of high/normal serum iron levels, and predicts exercise capacity: an …

V Santhirapala, LC Williams, HC Tighe, JE Jackson… - PLoS …, 2014 - journals.plos.org
Background Oxygen, haemoglobin and cardiac output are integrated components of oxygen
transport: each gram of haemoglobin transports 1.34 mls of oxygen in the blood. Low arterial …

[PDF][PDF] The role of persistent foramen ovale and other shunts in decompression illness

PT Wilmshurst - Diving Hyperb Med, 2015 - eubs.org
A persistent foramen ovale (PFO) and other types of right-to-left shunts are associated with
neurological, cutaneous and cardiovascular decompression illness (DCI). A right-to-left …

Cardiopulmonary exercise testing demonstrates maintenance of exercise capacity in patients with hypoxemia and pulmonary arteriovenous malformations

LSGE Howard, V Santhirapala, K Murphy, B Mukherjee… - Chest, 2014 - Elsevier
BACKGROUND Patients with pulmonary arteriovenous malformations (PAVMs) are unusual
because hypoxemia results from right-to-left shunting and not airway or alveolar disease …

Flight-related complications are infrequent in patients with hereditary haemorrhagic telangiectasia/pulmonary arteriovenous malformations, despite low oxygen …

CG Mason, CL Shovlin - Thorax, 2012 - thorax.bmj.com
Individuals with pulmonary arteriovenous malformations (PAVMs) and hereditary
haemorrhagic telangiectasia (HHT) commonly have low oxygen saturations and anaemia …