Chondrosarcoma is the second most common primary bone malignancy, representing one
fourth of all primary bone sarcomas. It is typically resistant to radiation and chemotherapy …

Head and neck squamous cell carcinoma (HNSCC) is the 6th most common human cancer
and affects approximately 50,000 new patients every year in the US. The major risk factors …

In cancer cells, metabolic adaptations are often observed in terms of nutrient absorption,
biosynthesis of macromolecules, and production of energy necessary to meet the needs of …

ABSTRACT TP53‐induced glycolysis and apoptosis regulator (TIGAR), a glycolytic inhibitor,
plays vital roles in regulating cellular metabolism and oxidative stress. However, the role of …

Metabolic heterogeneity between neoplastic cells and surrounding stroma has been
described in several epithelial malignancies; however, the metabolic phenotypes of …

Alteration in glucose homeostasis during cancer metabolism is an important phenomenon.
Though several important transcription factors have been well studied in the context of the …

Background High oxidative stress as defined by hydroxyl and peroxyl activity is often found
in the stroma of human breast cancers. Oxidative stress induces stromal catabolism, which …

Metastasis formation accounts for the majority of tumor-associated deaths and consists of
different steps, each of them being characterized by a distinctive adaptive phenotype of the …

Cancer cells adopt glycolysis to facilitate the generation of biosynthetic substrates
demanded by cell proliferation and growth, and to adapt to stress conditions such as …

Cognitive deficit is one of the challenging complications of type 2 diabetes. Sphingosine 1-
phosphate receptors (S1PRs) have been implicated in various neurodegenerative and …